摘要
目的 :比较几种新瘤标对膀胱移行细胞癌早期诊断的价值。方法 :对 32 2例肉眼或镜检血尿、膀胱刺激症状或发现膀胱占位者 ,在作膀胱镜检查前行尿液中细胞角蛋白 2 0 (CK2 0 )、核基质蛋白 (NMP2 2 )、Immuno Cyt、膀胱肿瘤抗原 (BTAstat)检测和常规尿细胞学检查 ,比较它们的敏感性和特异性。 结果 :经膀胱镜和病理检查诊断膀胱移行细胞癌 14 9例 ,其中浅表性肿瘤 110例 ,浸润性 39例 ;G181例 ,G2 4 6例 ,G3 2 2例。CK2 0、NMP2 2、ImmunoCyt、BTAstat、尿细胞学和膀胱镜检的敏感性分别为90 .6 %、85 .2 %、82 .6 %、6 5 .8%、30 .2 %和94 .6 % ,特异性分别为 83.6 %、84 .0 %、78.1%、6 4 %、10 0 %和 10 0 %。结论 :新瘤标CK2 0、NMP2 2、ImmunoCyt具有较高的敏感性 ,与BTAstat和尿细胞学比较 ,差异有统计学意义 。
Objective:To evaluate and compare the role of new tumor markers in the early detection of bladder cancer.Method:Cytokeratin 20, nuclear matrix protein 22, ImmunoCyt, BTA stat and conventional urinary cytology were studied before cystoscopy in 322 patients, who with gross or microscopic hematuria, bladder irritative symptoms and bladder space-occupying lesions. Sensitivity and specificity were compared tumor markers with cytology and cystoscopy.Result:Transitional cell carcinoma of the bladder was diagnosed in 149 cases, including Tis^T 1 stage tumor 110 cases and T 2~T 3 stage tumor 39 cases, G 1 81 cases, G 2 46 cases, G 3 22 cases. Sensitivity of CK20, NMP22, ImmunoCyt, BTA stat, urine cytology and cystoscopy was 90.6%, 85.2%, 82.6%, 65.8%, 30.2% and 94.6%, respectively; Specificity was 83.6%, 84.0%, 78.1%, 64.0%, 100% and 100%, respectively.Conclusion:New tumor markers, CK20, NMP22 and ImmunoCyt, have high sensitivity and specificity. Differences, compared with BTA stat and cytology, have statistic significance. New tumor markers are reliable to use in the early detection of the bladder cancer.
出处
《临床泌尿外科杂志》
2004年第3期151-153,共3页
Journal of Clinical Urology
关键词
膀胱肿瘤
诊断技术
泌尿外科
瘤标
Bladder neoplasms, carcinoma
Diagnosis
Tumor marker
