摘要
目的探讨乙型病毒性肝炎肝硬化门脉高压性胃病(PHG)与HBV感染的关系。方法对143例乙型病毒性肝炎肝硬化并PHG患者进行纤维胃镜检查,并取胃粘膜组织进行病理检查和免疫组织化学检查HBV抗原,同时采用ELISA和PCR检查血中HBV抗原及HBVDNA。PHG病变分为轻、中、重3度。对照组为非门脉高压的慢性HBV感染者。结果血中HBV抗原及HBVDNA两组无显著性差异。PHG胃粘膜组织中HBsAg和HBcAg阳性率明显高于对照组(P<0.01),分别为36.36%和25.87%,对照组分别为27.61%和16.67%。PHG病变越重者组织中HBV抗原阳性率越高,PHG轻、中、重度各组HBsAg阳性率分别为20.96%、29.78%和64.70%,HBcAg阳性率分别为16.12%、25.53%和44.11%,三组间的阳性率比较均有显著性差异(P<0.01)。结论PHG的发病可能与HBV感染有关。
Objective To investigate the relationship between portal hypertension gastrosia (PHG)and HBV infection using immunohistochemistry technique.Method The143cases of liver cirrhosis with PHG were given endoscope examination and gastric mucosa was taken for pathology examination.HBV antigen in gastric mucosa was detected by immunohistochemistry and HBV antigen and HBV DNA in serum were detected by ELISA and PCR respectively.The pathologic changes were divided into slight ,moderate and severe degrees.The control group were the patients with chronic HBV infection without portal hypertension.Results No marked difference could be found between two groups.The positivity rate of HBsAg and HBcAg in gastric mucosa in the studied group was higher than that in the control group,36.36%and25.87%vs27.61%and16.67%,respectively (P<0.01),indicating that there was positive correlation between the degree of PHG pathology and the positivity rate of HBV antigen in gastric mucosa.The HBsAg positivity rate of slight,moderate and severe degrees of PHG was20.96%,29.78%and64.70%respectively and HBcAg positive rate was16.12%,25.53%and44.11%respectively,(P<0.01).Conclusion The prevalence of PHG would be related to HBV infection.
出处
《实用医药杂志》
2003年第5期357-358,共2页
Practical Journal of Medicine & Pharmacy
关键词
门脉高压性胃病
乙型肝炎病毒
免疫组织化学
聚合酶链反应
Portal hypertension gastrosia Hepatitis B virus Immunohistochemistry Polymerase chain reaction
