摘要
目的 了解涎腺腺样囊性癌 (SACC)远处转移和生存率与微血管密度 (MVD)的相关性。方法 用CD34-McAb对 31例SACC患者的石蜡切片进行SP免疫组化染色 ,2 0 0倍光镜下对MVD计数 ,并进行统计学处理。结果 时序检验结果显示MVD分组间的生存率存在显著性差异 ,Cox模型多因素分析显示仅MVD可选入该模型 ;远处转移组的MVD值显著高于无转移组 ,高MVD组的远处转移率显著高于低MVD组。结论 MVD对SACC的远处转移及生存预后有显著相关性 。
Objective To elucidate the correlation of the microvessel density(MVD) and the incidence of metastasis and the survival rate of the patients with the salivary adenoid cystic carcinoma (SACC).Methods After the follow-up of 31 primary patients with SACC treated between 1981 and 1997,the immunohistochemical technique against CD34 was applied to stain the sections of paraffin-embedded tumor tissue,then followed by the MVD values of each section were numberated by two pathologists.The data subsequently were processed by the statistic software.Results The univariate statistical analyses of the data by the log-rank test showed that MVD was a statistically significant variable for the survival of the patients with SACC.Furthermore,among the relevant variables,only MVD had the independent prognostic value for the survival of patients with SACC in the Cox proportional hazard model.While the MVD value was statistically significantly higher in the group with distant metastasis than those without metastasis,the incidence of distant metastasis correspondingly was statistically significantly higher in the patients with high MVD value(≥60/×200) than those of the counterpart.Conclusion The MVD value has a statistically significant correlation to the incidence of distant metastasis and the survival of patients with SACC.Furthermore,MVD may be applied as an independent prognosis indicator for the survival of those patients.
出处
《现代口腔医学杂志》
CAS
CSCD
2004年第2期134-137,共4页
Journal of Modern Stomatology
关键词
微血管密度
涎腺腺样囊性癌
肿瘤远处转移
预后
预后
Adenoid cystic carcinoma Salivary gland Angiogenesis Neoplasm metastasis Prognosis
