摘要
目的 运用Meta 分析的方法综合评价parkin基因S/N16 7多态性与帕金森病 (PD)发病的关系。 方法 检索Medline、Cochrane图书馆 (英文 )和中国生物医学文献数据库 (CBM ) (中文 ) ,纳入内容涉及parkin基因S/N16 7多态的基因型频率和 (或 )等位基因频率的独立病例对照研究 ,同时手检并纳入了我们研究组未发表的文献。各文献满足研究方法相似 ,有综合的统计指标。研究年限为 1998～ 2 0 0 3年。语种不限。排除不符合纳入标准 ,未涉及S/N16 7多态基因频率的对照研究。应用RevMan4 .2软件进行统计分析。结果 合并统计 ,总体效应检验未发现统计学上的差异 (Z =1.5 7,P =0 .12 ) ,但根据东西方人群进行分组分析后发现 ,S/N16 7多态在基因型水平 [OR =1.4 1,95 %CI =(1.0 8,1.83) ,P =0 .0 1]和等位基因水平 [OR =1.2 5 ,95 %CI=(1.0 8,1.4 4 ) ,P =0 .0 1]均可能增加东方人群患PD的发病风险。加入我们研究组的未发表资料后 ,上述结论未改变 ,趋势更明显。而西方人群在基因型水平 [OR =0 .5 5 ,95 %CI =(0 .30 ,1.0 2 ) ,P =0 .0 6 ]和等位基因水平 [OR =0 .5 5 ,95 %CI =(0 .2 8,1.0 8) ,P =0 .0 8]均无统计学上的差异。结论 我们的Meta 分析结果提示 ,S/N16 7多态性可能增加了东方人群患PD的危险性 ,对西?
Objective To investigate the association between parkin gene S/N167 polymorphism and the risk for Parkinson’s Disease (PD) using the methods of meta-analysis. Methods References were retrieved through the computerized Medline, Cochrane Library and CBM search from 1998 to 2003. Similar search strategies were applied to each of these databases. The unpublished data of our study were also included.Studies eligible for this meta-analysis should meet the following inclusion criterias: ① presentation of original data and a cross-sectional design. ② PD as the outcome of interest. ③ an odds ratio (or enough information to calculate it) reported to quantify the association between the frequencies of genotypes and alleles of parkin gene S/N167 polymorphism and the risk for PD. All analyses were conducted with ‘Review Manager’ Version 4.2 software. Results A total of 1 239 PD patients and 1 168 control studies were studied. The combined data statistics revealed the frequencies of the genotypes and alleles were higher, but showed no statistically difference, for the total PD group from that of the control group (Z=1.57, P=0.12). After stratification according to eastern or western origin, the frequencies of G/A+A/A genotype and a allele of eastern origin were significantly higher [test for overall effect: P=0.01, OR=1.41, 95%CI=(1.08,1.83); P=0.01, OR=1.25, 95%CI=(1.08,1.44), respectively\]), respectively\] in the PD group than that in the control group. After including our unpublished data, the results remained constant, and the trend was much more pronounced. Conversely, t here was no difference [test for overall effect: P=0.08, OR=0.5 5, 95%CI=(0.30,1.02); P=0.08, OR=0.55, 95%CI=(0.28,1.08)\] in th e frequencies of allele and genotype of western origin between the PD patients a nd the controls.〓Conclusions〓The meta-analysis suggests t hat the parkin gene S/N167 polymorphism might be a genetic risk factor for PD of eastern origin, but not a definite risk for PD of western origin.
出处
《中国循证医学杂志》
CSCD
2004年第3期157-163,共7页
Chinese Journal of Evidence-based Medicine
基金
国家科技攻关计划项目
项目编号 :2 0 0 2BA711A10
北京市自然科学基金项目
项目编号:70 3 10 0 2
北京市卫生局首都发展基金项目
项目编号:2 0 0 2 -3 0 11
北京市科委项目
项目编号 :95 5 0 2 0 5 0 0~~
