摘要
目的探讨外周血白细胞及中性粒细胞对亚低温治疗重型颅脑损伤的临床疗效评估。方法120例经手术治疗后的重型颅脑损伤患者,随机分为亚低温组和对照组。亚低温组于手术后予亚低温治疗,直肠温度降至33～35℃,对照组体温维持存36.5～37.5℃。共治疗3～7 d,分别于术后第1 d和第8 d对两组患者的外周血WBC及中性粒细胞进行检测和GCS进行评估,6个月后进行GOS预后评估。结果亚低温组和对照组在术后第1 d的GCS和WBC及中性粒细胞没有显著性差异,但到第8 d则表现出明显的差异性,亚低温组的GCS及WBC和中性粒细胞均优于对照组(P<0.01或P<0.05);随访6个月亚低温组GOS预后显著优于对照组(P<0.01)。结论亚低温是治疗重型颅脑损伤的有效手段之一,并且外周血WBC及中性粒细胞的变化是评估颅脑创病人预后的客观指标之一。
Objective To evaluate the clinical therapeutic effects of mild hypothermia on severe brain trauma by detecting the white blood cell (WBC) and neutrophilic granulocyte (N) in the peripheral blood. Methods 120 patients with severe brain trauma were divided randomly into treatment and control groups. After operation on all, the former group underwent mild hypothermia therapy with their rectum temperature decreased to 33-35℃ and the latter with their body temperature at 36.5-37.5℃. On the first and eighth day postoperatively, the GCS was evaluated and the WBC and N in the peripheral blood were examined. In 6 months, their GOS was evaluated in both groups. Results The GCS, WBC and N in treatment group were significantly superior to those in control group (P<0.01 or 0.05) on the eighth day but insignificantly on the first day. The GOS in hypothermia group was superior to that in control group (P<0.01) for 6 months follow-up. Conclusion Mild hypothermia is effective in treating severe brain trauma. WBC and N are useful in objectively evaluating the prognosis of patients with severe craniocerebral trauma.
出处
《中华神经医学杂志》
CAS
CSCD
2004年第2期111-113,共3页
Chinese Journal of Neuromedicine
