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凋亡素特异性诱导肿瘤细胞凋亡分子机制 被引量：1

The Molecular Mechanism of Apoptin Inducing Tumor-Specific Apoptosis
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摘要 来源于鸡贫血病毒(CAV)的凋亡素(apoptin)能选择性地诱导肿瘤细胞和转化细胞的凋亡,对正常人二倍体细胞无影响,而且它诱导的凋亡不依赖p53介导,不被bcl鄄2抑制,使其成为一种有前景的抗肿瘤制剂。该文就凋亡素诱导细胞凋亡的作用及其特异性诱导肿瘤细胞凋亡的分子机制进行综述。 Apoptin,the chicken anemia virus-derived protein,induces apoptosis in a p53-independent and bcl-2-stimulated manner in transformed and tumorigenic human cells.It is a potential agent for tumor therapy.This review summarizes the characteristics of apoptin-induced apoptosis and the molecular mechanism by which apoptin induces tumor cell apoptosis.
作者 苏海英 谢宛玉
机构地区 南华大学附属第一医院
出处 《中国肿瘤》 CAS 2004年第3期160-163,共4页 China Cancer
关键词 鸡贫血病毒 凋亡素 细胞凋亡 肿瘤细胞 chicken anemia virus apoptin apoptosis tumor cell
分类号 R73-3 [医药卫生—肿瘤]
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参考文献22

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中国肿瘤
2004年 第3期

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