摘要
目的观察川芎嗪的抗炎作用与组胺、5-羟色胺的关系。方法采用荧光法测定炎性渗出物中组胺、5-羟色胺的含量,用豚鼠离体回肠收缩实验观察川芎嗪对组胺、5-羟色胺的作用。结果川芎嗪能显著降低大鼠炎性渗出物中组胺、5-羟色胺的含量,显著拮抗组胺、5-羟色胺所致豚鼠离体回肠的收缩。结论川芎嗪的抗炎作用可能与其抑制组胺、5-羟色胺的合成或释放,及对组胺、5-羟色胺的直接拮抗作用有关。
Objective To investigate the relationship of the anti-inflammatory effects of tetramethylprazine with histamine and 5-hydroxytryptaphane(5-HT).Methods The contents of histamine and 5-HT in the inflammatory exudate of rats were determined by fluorescence technique.The effect of tetramethylprazine on histamine and 5-HT were analyzed by in-vitro ileum contraction test in guinea pigs.Results Tetramethylprazine significantly decreased the contents of histamine and 5-HT in the inflammatory exudate,and markedly antagonized the contraction of isolated ileum induced by histamine and 5-HT.Conclusion The anti-inflammatory mechanisms of tetramethylprazine may be related to the inhibition of the synthesis or release of histamine and 5-HT,as well as its direct antagonism.
出处
《中药新药与临床药理》
CAS
CSCD
2004年第2期93-94,共2页
Traditional Chinese Drug Research and Clinical Pharmacology
关键词
川芎嗪
抗炎
组胺
5-羟色胺
Tetramethylprazine
Anti-inflammatory effects
Histamine
5-hydroxytryptamine
