摘要
目的:研究经数字减影血管造影术(DSA)介入舌动脉灌注及静脉注射抗癌药物后,血和局部组织中药物浓度,以及肝肾功能、血相变化,为临床介入治疗提供实验依据。方法:将5只狗分为3组,第一组A、B2只狗,第二组C、D2只狗,第三组E1只狗,经股动脉DSA介入舌动脉灌注5-Fu、卡铂各75mg,明胶海绵栓塞;另一组静脉注射等量5-Fu与卡铂,于10min、20min、30min至5天,检查舌、颊组织及血中药物浓度、肝肾功能、血常规,6周后处死,行舌动脉病理检查。结果:DSA介入舌动脉药物灌注+栓塞术后10min、20min、30min舌组织中药物含量是静脉注射药物的25、20、4倍,30min后血中药物浓度两组之间无显著性差异。肝肾功能、血常规两组差别不大,舌动脉经灌注后其内膜不完整,平滑肌细胞较多空泡样变。结论:DSA动脉介入灌注栓塞,可增加局部组织中抗癌药物浓度,提高药物的抗瘤性,对提高治疗效果有一定作用。
Objective: To study the concentration changes of anticancer drugs in plasma and local tissue as well as the changes of liver and renal function after lingual arterial perfusion under DSA and by intravenous injection.Methods: Two dogs of the first group were perfused with 75mg carboplatin and 75mg 5-Fu respectively from femoral artery to lingual artery by DSA techenique. Dogs of the other group were injected by vein the same amount of carboplatin and 5-Fu.10min,20min, 30min and 5 days after injection,drug concentration of blood and local tissues, liver and renal function, blood routine were examined. 6 weeks later,histopathologic effect was determined by animal biopsy. Results: Drug content of local tissues after DSA intervened infusion and embolization in different time intervals were significantly higher than that of intravenous injection.Drug contents of blood 30min after treatments showed no difference between two groups.There was also no significant difference in liver and renal function and blood routine test between two groups. Conclusions:Intraarterial infusion embolization under DSA can increase the drug in local issues and improve the effects of anti tumor drugs concentration.
出处
《中华老年口腔医学杂志》
2004年第1期2-6,共5页
Chinese Journal of Geriatric Dentistry
基金
青岛市科研基金课题(2001-014)
