摘要
目的 :探讨在常规治疗基础上 ,加用脑蛋白水解物 (施普善 )治疗流行性乙型脑炎的临床疗效及不良反应。方法 :70例流行性乙型脑炎患者 ,随机分成治疗组 3 6例 ,给予吸氧、退热、镇静、控制惊厥、甘露醇脱水等 ,酌情使用呼吸兴奋药、能量合剂等纠正呼吸衰竭 ,配合吸痰器、呼吸机等综合治疗的基础上 ,加用脑蛋白水解物 10～ 2 0mL ,加入5 %葡萄糖注射液 2 5 0mL中 ,静脉滴注 ,qd ,14d为 1疗程 ,治疗 2个疗程 ;对照组 3 4例 ,采用同治疗组的常规综合治疗 ,疗程同治疗组。结果 :疗程结束时 ,治疗组总有效率 91.7% ,对照组总有效率 61.8% ,治疗组的疗效明显优于对照组 ,二者差异有显著性 (P <0 .0 5 ) ,未见明显的药物不良反应。结论 :脑蛋白水解物治疗流行性乙型脑炎 ,疗效确切 ,安全有效 ,值得在临床推广。
Objective:To probe into the clinical therapeutic effectiveness and adverse reactions of cerebroprotein hydrolysate as an adjunct to the routine measures for the treatment of epidemic encephalitis B. Methods:70 patients with epidemic encephalitis B were randomly divided into 2 groups, the treatment group( n =36)and control group( n =34). On the basis of routine combined treatment including oxygen inhalation, antifebrile measures, sedation, control of convulsion, dehydration with mannitol, rational use of respiratory stimulants and energy mixtures to combat respiratory failure supported by sputum aspirator and respirator, patients of the treatment group were given each 10～20 mL of cerebroprotein hydrolysate added to 250 mL of 5% glucose solution administered by IV instillation, q.d.. The patients were subjected to 2 courses of treatment, with each course lasting 14 days. Patients of the control group were submitted only to the routine combined treatment. The course of treatment was the same as that of the treatment group. Results:By the termination of the course of treatment, the overall effective rates were 91.7%and 61.8% for the treatment group and control group, respectively. The therapeutic effectiveness in patients of the treatment group was superior to that of the control group ( P < 0.05) . No distinct adverse reactions were encountered. Conclusion:Cerebroprotein hydrolysate was shown to have definite therapeutic effectiveness in the treatment of epidemic encephalitis B and is therefore worth spreading its clinical application.
出处
《医药导报》
CAS
2004年第4期225-226,共2页
Herald of Medicine
