摘要
核因子Κb是一种具有基因转录多项调控作用的转录因子.Sen等[1](1986)首先从B淋巴细胞核抽提物中,检测到一种能与免疫球蛋白κ链基因增强子Κb序列特异性结合,并能促进κ基因表达的核蛋白因子,称之为核因子-Κb(nuclear factor-kappa B,NF-κB).
NF-κB is one of important transcription factors, which plays an important role in many immune and inflammatory responses. The novel data showed that the NF-κB pathway was also detectable in myocardial cells, vascular endothelial and smooth muscle cells, and involved in the development of many car-diovascular diseases. The present review gives a detail presentation of current advances on relationship betweenNF-κB and cardiovascular diseases.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2004年第3期493-496,共4页
Chinese Journal of Pathophysiology
关键词
NF-ΚB
心血管疾病
NF-kappa B
Cardiovascular diseases
