摘要
聚乙醇酸类生物降解高分子具有良好的生物相容性,在药物缓释材料、组织工程材料、手术缝合线等医用领域有广泛的应用。文章按聚乙醇酸类生物降解高分子的种类不同,介绍了它们的合成、性能与应用,尤其是乙醇酸-乳酸共聚物的研究进展。展望聚乙醇酸类生物降解高分子的未来,降低合成成本是广泛应用的关键,因此简单易行的、以乙醇酸等单体为原料的直接缩聚法合成值得关注。
Polyglycolic acid biodegradable polymers have good biocompatibility, and have extensive application in the medicine fields, such as drug delivery material, tissue engineering scaffold, and surgical suture. The synthesis, properties and application of different kinds of polyglycolic acid biodegradable polymers are introduced in this paper, especially the research progress of poly (lactic acid-glycolic acid) (PLGA) are reviewed in detail. The future study on polyglycolic acid biodegradable polymers should be emphasized on reducing their synthesis cost, and the simple and practicable direct polycondensation method using glycolic acid as starting monomer is noticeable.
出处
《广州化学》
CAS
2004年第1期50-57,共8页
Guangzhou Chemistry
基金
广东省自然科学基金资助项目(020885)
关键词
聚乙醇酸
乙醇酸-乳酸共聚物
生物降解高分子材料
直接缩聚法
合成
polyglycolic acid biodegradable polymer
poly(lactic acid-glycolic acid) (PLGA)
copolymer
synthesis
ring-opening polymerization
direct polycondensation
