摘要
本研究给雄性大鼠饲喂克山病病区粮,以及补加维生素 E(VE)和/或硒,观察其血清促甲状腺激素(TSH)、催乳素(PRL)、促黄体激素(LH)、卵泡刺激素(FSH)及睾丸酮(TS)水平变化。结果表明,饲喂克山病病区粮,大鼠血清 TSH 水平明显增高(P<0.01),血清 PRL 水平轻度增高(P>0.05),而血清 LH、FSH 和 TS 水平轻度降低(P>0.05);补加 VE和/或硒,减轻了饲喂病区粮而引起的上述各指标改变。提示,饲喂克山病病区粮,可能直接影响垂体前叶 TSH 细胞,增强甲状腺轴的功能,而对垂体前叶 PRL 细胞及性腺轴的影响不十分明显;向病区粮补加 VE 和/或硒,可减轻其病区粮的上述影响。VE 缺乏,如同低硒,在克山病发病中起到重要作用。
In the present study we observed the changes of serum TSH,PRL,LH,FSH and testosterone (TS) levels in male rats fed with the grains from endemicareas of Keshan disease and the grains added with vitamin E(VE)and/orselsnium(Se).The results showed that serum TSH level increased very significantly (P<0.01),serum PRL level increased slightly (P>0.05),andserum LH,FSH and TS levels all decreased slightly (p>0.05) in male rats fedwith the grains,while the grains added with VE and/or Se weakened thechanges of the grains on the above-mentioned indices.These suggest that thegrains from endemic areas of Keshan desease may mainly act directly on TSHcells of adenohypophysis and enhance the function of thyroid axis,but not soeffective on PRL cell of adenohypophysis and gonad axis in male rats.Thegrains added with VE and/or Se may weaken the effects of the grains.The lackof VE,as the lack of Se,may be an important factor in causing keshandisease.
出处
《中国地方病学杂志》
CAS
CSCD
1992年第2期72-75,共4页
Chinese Jouranl of Endemiology
关键词
维生素E
硒
内分泌素
克山病
Grains from the endemic areas of keshan disease
Vitamin E(VE)
Selenium(Se)
TSH
PRL
LH
FSH
Testosterone(Ts)
