摘要
目的 :测定抗凝血酶Ⅲ活性以期探讨在妊高征、糖尿病、肾病综合征、系统性红斑狼疮和急性非淋巴细胞白血病中的变化及意义。方法 :采用发色底物法分别对妊高征、糖尿病、肾病综合征、系统性红斑狼疮和急性非淋巴细胞白血病及其对照测定抗凝血酶Ⅲ。结果 :( 1)妊高征者和正常孕妇AT -Ⅲ :A :AT -Ⅲ :A明显低于正常非孕妇女 (P <0 .0 1) ,并且妊高征者比正常孕妇降低更甚 (P <0 .0 0 1)。 ( 2 )糖尿病无并发症组AT -Ⅲ :A与对照组比较 ,差异无显著性 (P >0 .0 5 ) ,糖尿病有并发症组与对照组比较 ,AT -Ⅲ :A显著降低 (P <0 .0 1)。 ( 3)肾病综合征患者AT -Ⅲ :A明显低于正常对照组 (P <0 .0 1)。 ( 4 )系统性红斑狼疮病人AT -Ⅲ :A显著低于对照组 (P <0 .0 1)。 ( 5 )急非淋AT -Ⅲ :A明显低于正常对照组 (P <0 .0 5 )。结论 :检测AT -Ⅲ
Objective:To investigate thc changes and clinical significance of antithrombin Ⅲin pregnancy induced hyperternsion(PIH),diabetes mellitus(DM),nephritic syndrome(NS),systemic lupus erythematosus(SLE) and acute non-lymphoid cell leukemia(ANLL).Methods:AT-Ⅲ:A was measured by chromogonic substratc method in pregnancy induced hypertension(PIH),diabetes mellitus(DM),nephritic syndrome(NS),systemic lupus erythematosus(SLE),acute non-lymphoid cell leukemia(ANLL) and control group.Results:AT-Ⅲ:A in women with PIH and normal prcgnancy and the DM with conplication and the NS and the SLE and the ANLL was significantly lower than that in the control.No significant difference in AT-Ⅲ:A was found between the DM without complication and the control.Conclusion:Determination of AT-Ⅲ:A has great value in the diagnosis of thrombophilia.
出处
《重庆医科大学学报》
CAS
CSCD
2004年第2期208-210,共3页
Journal of Chongqing Medical University
关键词
抗凝血酶Ⅲ
妊高征
糖尿病
肾病综合征
系统性红斑狼疮
急性非淋巴细胞白血病
Antithrombin Ⅲ
Pregnancy induced hypertension
Diabetes mellitus
Nephritic syncdrome
Systemic lupus erythematosus
Acute non-lymphoid cell leukemia
