摘要
在光动力学治疗时,理想的光照射应该是选择被传输光线的最佳分布去匹配靶位(肿瘤)组织的光学特性和几何形状。至今光在组织中传播的理论描述还不完善,组织光学特性的数据十分不足,施行PDT的曝光量带有极大的经验性。我们设计并实现了一种组织的光学模型,它能模拟典型组织的光学特性。一组优选的模型光学数据如下:散射系数306.5cm^(-1),吸收系数0.1cm^(-1),平均散射余弦0.86,漫射长度0.22cm和漫射系数0.012cm。这个光学模型可以重现典型人体组织中630nm激光辐射能流率的空间分布。
The ideal irradiation in PDT is to optimize the distribution of delivered light tomatch the geometric and optical characteristics of the target tumor tissue. At present,the theoretical description of the propagation of light in tissue is poorly developed, anddata on the optical properties of tissues are very sparse. Thus, radiant exposures are largelyempirical, with little account being taken of the spatial distribution of absorbed light en-ergy in the target tissue volume. A Liquid tissue-simulating phantom has been designedand carried out to pimulate the optical properties of typical tissue. A set of relevant datafor the optical parameter of phantom was found as follows: scattering coefficient 306.5cm^(-1), absorption coefficient 0.1cm^(-1), mean cosine of scattering angle 0.86, diffusionlength 0.22cm and diffusion coefficient 0.012cm. This optical phantom may duplicate thespatial variation of the radiant energy fluence rate of typical human tissues at 630nm wave-length in PDT.
出处
《中国激光医学杂志》
CAS
CSCD
1992年第3期131-134,共4页
Chinese Journal of Laser Medicine & Surgery
基金
国家自然科学基金
国家教委回国留学人员资助项目
福建省自然科学基金
关键词
模拟组织
光学模型
光疗法
Optical tissue-simulating phantom
Optical Property
Photodynamic therapy
