摘要
目的 研究白塞病合并白血病的临床特征 ,探讨两者间的关系。方法 报道 2例白塞病合并白血病病例 ,结合文献报道的 9例 ,共计 11例进行临床分析。结果 11例患者平均年龄 4 2 .4岁 ,平均病程 11.5年。临床表现按发生率多少分别为 :口腔溃疡 (10 0 .0 % )、皮损 (90 .9% )、外阴溃疡 (6 3.6 % )、眼部病变 (5 4 .5 % )和关节炎 (5 4 .5 % )。本组患者在合并白血病前大多有不同程度的外周血象改变 (6 /7例 ) ,并且有免疫抑制剂使用史(5 /8例 )。合并的白血病 :急性髓细胞性白血病 9例 ,急性淋巴细胞白血病和浆细胞白血病各 1例。 11例患者 1年内均死亡。结论 从发病诱因、临床表现、药物使用等方面分析 ,白塞病与白血病之间存在密切联系。
Objective To study the clinical characteristics of Behcet's disease coexisting with leukemia and appraise the interrelationshp of the two diseases. Methods A total of eleven cases including two of our own and nine in the medical literature were analyzed. Results The mean age of the 11 patients was 42.4 years, the average course of illness was 11.5 years. The clinical characteristics were: ulceration in the oral cavity (100.0%), skin lesion (90.9%), ulceration of vulva (63.6%), eye lesion (54.5%) and arthritis (54.5%). Cases coexisted with leukemia usually showed varying degrees of peripheral blood changes (6/7 cases) and history of immunosuppressive therapy (5/8 cases). Among these, nine cases were coexisted with acute myelocytic leukemia, and another two cases with acute lymphoblastic leukemia plasma cell-leukemia respectively. All patients died with in one year. Conclusions Close relationship can be seen between Behcet's disease and leukemia from the point of views concerning the provocating factors, clinical features and drug use.
出处
《上海医学》
CAS
CSCD
北大核心
2004年第2期119-121,共3页
Shanghai Medical Journal
