摘要
本文应用硫代巴比妥酸(TBA)法对34例格林—巴利综合征(GBS)患者51次血清唾液酸(SA)测定。结果显示:患者血清SA含量显著高于50例对照组,血清SA阳性率亦显著高于对照组;GBS患者四肢肌力与血清SA呈负相关;以重型GBS血清SA含量显著高于轻型,病程初期高于患病后期;血清磷脂含量GBS明显高于对照组,而血清胆固醇两组变化无显著性意义。本文提示GBS血清SA含量变化能够反映周围神经损伤的程度。
Serum sialic acid (SA) level was measured in the patients with Guillain-Barre syndrome (GBS)and normal controls.The results showed that the serum SA level (788.1±23.8mg/L) in 51 of patients with GBS was significantly higher than that (538.1±8.9mg/L) in 50 normal controls (P<0.001).The positive rate of serum SA in the patients (36/51) was significantly higher than that in normal controls (3/50,P < 0.001).There was a significantly negative linear correlation between the muscular weakness of four limbs in the patients and serum SA level (r=-0.464,P <0.0005).The serum SA concentration in the severe patients was significantly higher than that in the mild ones (P<0.05) and in the early period of illness was significantly higher than that in the post-illness period.The serum phospholipid level in the GBS group was significantly higher than that in the normal controls.However,the difference of serum cholesterol level was insignili-cant between two groups.The results suggest that serum SA concentration in patients with GBS might refect the damage degree of the peripheral nerve myelin.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
1992年第5期271-274,共4页
Chinese Journal of Nervous and Mental Diseases
关键词
神经根炎
唾液酸
磷脂
胆固醇
Guillain-Barre syndrome Serum sialic acid Phospholipid Chloes-terol.
