摘要
目的评价血清、尿胱抑素C(cystatin C, CC)浓度对肾组织纤维化的间接诊断价值。方法采用酶连免疫吸附试验(enzyme linked immunosorbent assay, ELISA)检测健康者及纤维化程度不同的慢性肾脏病患者血清和尿胱抑素C浓度。结果(1)慢性肾脏病患者血清CC浓度较正常对照组明显升高。以血清CC浓度显著增高来判断肾组织纤维化敏感度为82.4%,特异度为95%,准确度为85.9%。(2)肾纤维化各组尿CC浓度明显高与无纤维化组和正常对照组。以尿CC浓度显著增高来判断肾组织纤维化敏感度为76.5%,特异度为95%,准确度为81.7%。结论在排除肾外脏器慢性疾病的前提下,血清、尿CC浓度可作为慢性肾脏病患者肾组织纤维化的一项无创性检查指标。
Objective:To evaluate the indirect diagnosis value of serum and urine CC concentration for the renal fibrosis.Methods:The serum and urine CC concentration in all patients and ten health people were measured by enzyme linked immunosorbent assay(ELISA).Results:The serum CC concentration were higher than of health people(P<0.01).The judge ment of renal fibrosis by the serum CC concentration was centitire,specifil and accurate significantly.It's sensitivity,specificity and accuracy were82.4%,95%,and85.9%,respectively.The urine CC concentration of light fibrosis group,middle fibrosis group and CRF group was significantly higher than that of health group and no fibrosis group(P<0.05).It's sensitivity and speci-ficity reached76.5%and95%respectively and accuracy was81.7%.Conclusions:The serum and urine CC concentration might be diagnosis index for renal fibrosis under the condition that other organ chronic disease could be excluded,especially suitable for those patients who could not receive renal biopsy.
出处
《中国现代医学杂志》
CAS
CSCD
2004年第7期39-43,共5页
China Journal of Modern Medicine
关键词
胱抑素C
肾
纤维变
cystatin C
kidney
fibrosis
