摘要
目的 观察非甾体类抗炎药来比林与芬太尼合用于鼻内镜术 (ESS)后患者静脉滴注自控镇痛的效果。方法 鼻内镜手术 6 0例 ,静吸复合全麻 ,术后 4 8h内患者静脉滴注自控静脉镇痛 (PCIA)。患者随机分为两组 ,实验组 30例 ,芬太尼 0 .8mg ,来比林 2 .7g ,溶于 1 0 0ml生理盐水中 (芬太尼 8μg/ml,来比林 2 7mg/ml)。对照组30例 ,芬太尼 1 .4mg ,溶于 1 0 0ml生理盐水中 (芬太尼 1 4 μg/ml)。背景速度均为 1ml/h ,PCIA 1ml/次 ,锁定时间4 0min。结果 两组术后 4 8h内均获得了满意的镇痛效果 (VAS <4 ) ,VAS评分和PCIA次数两组相似。实验组、对照组芬太尼用量分别为 (0 .5 1± 0 .0 3)mg和 (0 .91± 0 .0 6 )mg(P <0 .0 1 )。实验组不良反应少于对照组 ,其中镇静深度与对照组相比有显著性差异 (P <0 .0 5 )。结论 来比林可有效加强ESS术后芬太尼的镇痛作用 ,明显减少芬太尼用量及不良反应 。
Objective To evaluate the clinical effects of Fentanyl plus lysine acetyl salicylate(LAS) using patient cntrolled analgesia delivery in patients undergoing ESS.Methods After ESS (endoscope sinus surgery),60 adult patients were enrolled in a randomized,double blinded study.When patients were in the post anesthesia recovery room,PCIA(patient controlled intravenous analgesia) was initiated.Either Fentanyl 8μg/ml+ LAS 27mg/ml or Fentanyl 14μg/ml was given with a speed of 1ml/h,As soon as they complained of pain,a PCIA was used with a lockout interval of 40 min.Pain score,patient satisfaction and adverse effects were observed for 48h.Results Adequate analgesia(VAS<4) was achieved with either drug.Fentanyl consumption in the Fentanyl/LAS group was significantly less than in Fentanyl group [(0.51±0.03)mg vs (0.91±0.06)mg in 48 h].Significantly more adverse effects and sedation were observed in Fentanyl group( P <0.05).Conclusions The LAS injection can be used as an effective and safe adjuvant to Fentanyl for PCIA after ESS.This combination reduces dosage of Fentanyl and hence some of its adverse effects.
出处
《北京医学》
CAS
北大核心
2004年第1期52-54,共3页
Beijing Medical Journal
关键词
来比林
芬太尼
鼻内镜术
自控镇痛
术后
不良反应
非甾体类抗炎药
Lysine Acetyl Salicylate (LAS) Patient controlled intravenous analgesia(PCIA) Endoscope sinus surgery (ESS)
