摘要
应用两次给药的急性毒性法测定了雷公藤制剂中有毒成分的毒代动力学参数,结果小鼠体内半衰期为28.4 h。
Tripterygium wilfordii (TW) is an important herbal drug, its extract has been used to treat auto-immune diseases such as lupus erythematosus, rheumatoid arthritis etc. Over-dose of the drug showed significant toxic effects which led to damages of heart, kidney, hemopoiesis system, etc. Now, the toxicokinetics of the extract from TW (ethanol-ethyl acetate extract) was estimated by means of acute mortality method. The half life time of total toxicants of TW extract in mice was 28.4 h. This means that the elemination rate in the body is slow.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1992年第1期25-26,共2页
Journal of China Pharmaceutical University
关键词
雷公藤
毒性
药代动力学
Tripterygium wilfordii Hook. f
Toxicokinetics
