摘要
在大鼠腹主动脉狭窄和高盐摄入引起的高血压模型上,观察到口服牛磺酸治疗可显著降低动物血压,(20.8±4.0kPa VS非治疗组27.3±3.2 kPa.P<0.01)抑制高血压动物血浆CGRP的减少.改善动物血管条的舒张反应。实验结果提示,牛磺酸可能具有临床上抗高血压作用。
On the hypertension model induced by narrowing abdominal aorta and feeding saline in rats, it was found that the treatment with oral administration of taurine significantly attenuated hypertension (20. 8±4.0 vs. untreated group 27. 3 ± 3. 2 kPa. P < 0.01). markedly inhibited the increase in plasma endothelin. angiotensin 11. and throm-
boxane. and the decrease in plasma CGR-P; and that the therapy with taurine obviously improved the reactivity of aortic vessel to vasoactive substances. The results suggest that clinical therapy with taurine for hypertension may be feasible.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1992年第5期403-406,共4页
Chinese Pharmacological Bulletin
关键词
牛磺酸
高血压
血管活性多肽
taurine
gypertension
vasoactive peptides
rat
