摘要
目的明确常用化疗药丝裂霉素、长春新碱和5-F尿嘧啶掺入骨水泥后的释放及活性。 方法采用洗提法和MTT法测量药物的释放及活性。 结果 三种药物均可从骨水泥中释放并具有杀伤肿瘤细胞效应。 结论 骨水泥携带抗癌药具有抗肿瘤效应。
Objective To determine the release of mitomycin C, vincristine sulfate and 5-flauouracil mixed with bone cement and the anti-cancer activity of the released drugs. Methods The release of drugs was studied by elution test. The anti-cancer activity of drugs was assessed by MTT method. Results The release of those drugs can be detected within 10-14 days and their anti-cancer activity lasted about 12 or 24 hours on MTT method. The more volume of those drugs mixed with bone cement is, the more the release and anti-cancer activity is. Conclusion Those drugs released from bone cement have the effect of anti-cancer.
出处
《空军总医院学报》
2004年第1期23-24,共2页
Journal of General Hospital of Air Force,PLA
