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支气管哮喘支气管肺泡灌洗液中TXB_2、6-keto-PGF_(1α)的变化及临床意义探讨 被引量:1

STUDY ON CHANGES IN TXB_2 6-keto-PGF^1α OF IN PATIENTS WITH BRONCHIAL ASTHMA AND CLINICAL SIGNIFICANCE
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摘要 对14例外源性支气管哮喘和26例经X线、肺功能、血气分析检查均正常的对照者进行支气管肺泡灌洗(BAL),回收支气管肺泡灌洗液(BALF),应用放免法测定血和BALF中血栓素B_2(TXB_2)、6-酮-前列腺素F_1α(6-keto-PGF_1α)。结果:哮喘组血与BALF中TXB_2含量明显高于对照组,且在哮喘发作期呈明显正相关,而6-keto-PGF_1α两组无明显差异。 The bronchoalveolar lavage was performed in 14 patients with allergic bronchial asthma and in 26 normal subjects. The bronchoalveolar lavage fluid (BALF) was collected. The BALF and blood specimens were assayed for TXB_2 and 6-keto-PGF_1 α by radioimmunoassay. The results were as following. The TXB_2 concentration of blood and BALF of the patients with asthma was obviously higher than those of the control (P<0.05, P<0.01). There was a significant positive correlation between blood and BALF for TXB_2 concentration in patients with asthmatic attack(P<0.05). There were no marked difference between blood and BALF for 6-keto-PGF_1α concentration in patients with asthma and in normal subjects.
出处 《中国医科大学学报》 CAS CSCD 1992年第1期58-61,共4页 Journal of China Medical University
关键词 哮喘 血栓素B2 前列腺素 asthma bronchoalveolar lavage fluid TXB_2 6-keto-PGF_1
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参考文献2

  • 1李兵,国外医学呼吸系统分册,1989年,9卷,2期,78页
  • 2团体著者,中华结核和呼吸杂志,1984年,7卷,3期,186页

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