摘要
采用SO_2刺激法制成鼠慢性支气管炎(慢支)模型,通过绿脓杆菌气溶胶吸入的细菌气道粘附实验,观察加味玉屏风散对鼠气管粘膜细菌粘附的影响。扫描电镜下见服药的慢支模型鼠的气管粘膜表面病变及粘附的细菌数远少于不服药者,气管组织匀浆粘附细菌定量培养计数也相应显著减少。健康对照鼠在同样吸入绿脓杆菌气溶胶的情况下,其气管粘膜未受损,无细菌粘附。提示细菌粘附与气管粘膜受损密切相关,加味玉屏风散可能通过保护气管粘膜上皮或减轻气管粘膜损伤而对抗细菌粘附。
In order to observe the influence of modified Yu Ping Feng San (MYPFS) on bacterial adhesion of tracheal mucosa, four experiments of bacteral adhesion in pneumatic tract were conducted, in which mice of chronic bronchitis model (CBM) induced by SO_2 stimulation and another health controlgroup breathed in aerosol contained Pseudomonas aeruginosa under the same condition wereobserved. The results showed that, with scanning electron microscopy, ultrastructural lesions ontracheal mucosa surface and adhesive bacterial numer in CBM admininistrated MYPFS were far lessthan that in CBM without MYPFS (P<0.0O1), and quantitative culture of Pseudomonas aeruginosawith tracheal tissue homogenate was also markedly reduced. However, the tracheal mucosa ofhealthy control animals were intact, the adhesive bacteria were not found. It is suggested thatbacterial adhesion was closely related to the injury of tracheal mucosa, and MYPFS could play a roleof anti-bacterial adhesion through the protectior of tracheal mucosa ethelium or reduction of pneumatic tract injury. These were quite in accordance with the theories of traditional Chinesemedicine in 'strengthening body resistance to eliminate the pathogenic factor', so that they providedexperimental evidence for TCM tonics to prevent and treat infection of respiratory tract
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1992年第11期677-679,共3页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
细菌粘附
玉屏风散
支气管炎
experimental chronic bronchitis
bacterial adhesion
modified Yu Ping Feng San
