摘要
运用q值计算方法评价川芎嗪和阿魏酸的合并效应。实验发现两药合用对兔和大鼠离体主动脉痉挛性收缩的缓解作用、增加豚鼠心脏灌流量及降低大鼠全血粘度等作用与单用该两药相比呈协同;而对小鼠急性毒性,合用时毒性为拮抗。
The experiments showed that both tetramethylpyrazine and ferulic acid relaxed the norepinephrine-induced spasmodic contraction of rabbit and rat aorta strips, increased the coronary flow of isolated guinea pig hearts and reduced the whole blood viscosity in rats. Evaluated with Burgi's equation, the combined effect of these 2 drugs was obviously potentiated, but the combined acute toxicity in mice was greatly reduced.
出处
《中国中药杂志》
CAS
CSCD
北大核心
1992年第11期680-682,共3页
China Journal of Chinese Materia Medica
基金
国家自然科学基金 No.3860997
关键词
川芎嗪
阿魏酸
主动脉
血液粘度
tetramethylpyrazine
ferulic acid
aorta
heart
blood viscosity
