摘要
本文作者用两种不同的方药来预防激素造成的家兔股骨头坏死。在接受12.25mg/kg 强的松龙的对照组动物。发现动物有进行性高血脂,股骨头内的骨细胞空泡变和坏死,脂肪细胞膨大,骨小梁变细,毛细血管扩张和骨内压增高。同时,动物心、肝、肾、肺的细胞肿胀、变性甚至坏死。和对照组相比,中药骨通Ⅱ组的血清胆固醇和甘油三酯降低,骨细胞空泡变和坏死的百分率明显降低,P<0.01。同时发现骨小梁的横径较粗,脂肪细胞、毛细血管的病理改变较轻,骨内压也较低。骨通Ⅱ组的中药对内脏器官的细胞有明显的保护作用。骨通Ⅰ组的效果不如Ⅱ组,且有出血倾向。实验表明骨通Ⅱ组具有抗高血脂、预防类固醇激素造成的股骨头和内脏细胞坏死的作用。
In this article,two herbs fomularies were emploied for preventing of avascular necrosis of the femoral head in steroid-treated rabbits.The control rabbits,which were administered intramuscularly in 12.25 mg/kg/w Hydroprednisoni Acetas,caused advanced hypertipidemia,osteocytes vacuolating and necro- sis,fat cells enlarging,smaller bone trabeeulae,extending capillaris and increased bone marrow pressure with- in femoral head.Meanwhile,cells of the heart,liver,lungs and kidney became swelling,denatured,even necrosis.In the group of herbs 2,compared with the control one,the serum cholesterol and triglycerides de- creased and percentage of osteocytes vacuolization and necrosis decreased significantly,P<0.01,also,thicker trabeeulae in diameter and lighter pathological changes of fat cells,eapillaris were found.In addition,the herbs 2 prescription can protect cells of viscera from denatured and necrosis due to steroid.The effect of herbs 1 is infererior to the herbs 2,but there is a tendency towards hemorrhage.It showed that the heros 2 prescrip- tion have effects of anti-hyperlipidemia,prevention of necrosis of osteocytes and viscera cells due to steroid.
出处
《中国中医骨伤科杂志》
CAS
1992年第2期3-5,37,共4页
Chinese Journal of Traditional Medical Traumatology & Orthopedics
关键词
中药
骨通
股骨头坏死
预防
Herbs Gu-Tong
Necrosis of the femoral head
Prevention
