摘要
目的:初步探讨马尾神经损害导致马尾神经综合征,引以感觉障碍的原因。方法:纯种健康雄性新西兰兔40只,按随机数字表法分为3组,非手术对照组10只,手术不加压对照组10只,模型组30只;模型组再根据加压螺丝进入椎管矢状径的深度分为进入1/9,2/9,1/2。模型组加压装置置于S2～3压迫马尾神经组。取不同时间段的马尾神经综合征的模型的神经根的后根节,作HE染色对其内正常感觉神经元细胞记数。结果:临床出现马尾神经综合征1/2d,将导致双侧后根节缺血水肿,节内神经元细胞坏死。后根节的正常细胞记数:3,7,30d时非手术对照组左侧为(32.2±4.2),(32.2±4.3),(32.2±4.3)/mm2;手术不加压对照组左侧为(32.2±2.3),(32.2±4.3),(32.2±3.1)/mm2;实验组左侧为(17.2±3.3),(14.2±3.2),(14.1±2.3)/mm2;差异有显著性意义(P<0.05)。结论:背根结内的感觉神经元极敏感,极易坏死,是马尾神经损害顺行溃变的重要病理变化之一,是导致鞍区麻木、感觉障碍,难以恢复的重要原因。
AIM:To study the pathological mechanism of sensory disturbance caused by cauda equina nerve damage.METHODS:Fifty pure breed healthy male New Zealand rabbits were devided into th ree groups randomly: non-treatment group(10 rabbits);non-compression control g roup(10 rabbits) and trial group(30 rabbits).At the following time points(1/4,1/ 2,3,7 and 15 days).According to the of the compressor screw the sagittal diamete r of vertebral canal,the model group was divided into 1/9,2/9,1/2.The compressio n devices were fixed between S2 and S3 to compress cauda equina.Posterior root g anglion was removed from the model with cauda equina nerve syndrome at different time point,and stained with HE.The number of normal sensory neuron cells were c ounted.RESULTS:After cauda equina nerve syndrome occurred for 1/2 day,there was isch emia and edema in two sides of posterior root ganglion and cellular necrosis of neurons in ganglion.The number of normal cells in posterior root ganglion was 3 and 7.The left in unoperation control group at time point of 30d was 32.2±4.2,3 2.2±4.3,32.2±4.3/mm2; The left in uncomprssion operation group was 32.2±2.3,3 2.2±4.3,32.2±3.1/mm2;The left in experiment group was 17.2±3.3,14.2±3.2,14. 1±2.3/ mm2.There was significant difference between groups(P< 0.05).CONCLUSION:Sensory neurons in posterior root ganglion are very sensitive and e asily suffer necrosis,which is one of the important pathological changes of dire ct degeneration in cauda equina nerve damage and also explain why the numbness o f sella turcica region and sensory disturbance are hard to recover.
出处
《中国临床康复》
CSCD
2004年第11期2156-2157,共2页
Chinese Journal of Clinical Rehabilitation
基金
全军医学科研"十五"规划课题(01L056)~~
