期刊文献+

同源异型盒基因和乳腺癌相关性研究进展

下载PDF
导出
摘要 乳腺癌是威胁女性健康最常见的恶性肿瘤之一,其发生、发展过程涉及多种基因的参与,并与相关转录因子(transcriptive factor,TF)的调控作用关系密切。同源异型盒基因作为一类具有特定时空表达模式的转录调控因子,其表达蛋白不仅控制胚胎细胞的发育和分化,而且在成人组织中增殖、分化过程也发挥着主控作用。研究同源异型盒基因和乳腺癌的关系,有利于乳腺癌的早期诊断、治疗以及相关研究工作的进一步开展。
出处 《国外医学(遗传学分册)》 2004年第2期94-96,122,共4页 Foreign Medical Sciences(Section of Genetics )
  • 相关文献

参考文献25

  • 1Care A, Silvani A, Meccia E, et al. Transduction of the SkBr3 breast carcinoma cell line with the HOX-B7 gene induces bFGF expression, increases cell proliferation and reduces growth factor dependence. Oncogene, 1998, 16(25):3285-3289.
  • 2Ford HL,, Kabingu EN, Bump EA, et al. Abrogation of the G2 cell cycle checkpoint associated with overexpression of HS1X-1: a possible mechanism of breast carcinogenesis. Proc Natl Acad Sci USA,1998, 95(21 ):12608-12613.
  • 3Haga SB, Fa S, Karp JE, et al. BP1, a new homeobox gene, is frequently expressed in acute leukemia. Leukemia, 2000,14:1867-1875.
  • 4Jemal A, Murray T, Samuels A, et al. Cancer statistics, 2003. CA Cancer J Clin, 2003,53( 1 ):5-26.
  • 5Jiang X, Russo IH, Russo J. Alternately spliced luteinizing hormone/human chorionic gonadotropin receptor mRNA in human breast epithelial cells. Int J Oncol, 2002,20(4):735-738.
  • 6Raman V, Martensen SA, Reisman D, et al. Compromised HOX-A5 function can limit p53 expression in human breast tumors. Nature,2000, 405(6789): 974-978.
  • 7Zhang X, Zhu T, Chen Y, et al. Human growth hormone-regulated HOX-A1 is a human mammary epithelial oncogene. J Biol Chem.2003, 278(9): 7580-7590.
  • 8Srebrow A, Friedmann Y, Ravanpay A, et al. Expression of HOX-A1 and HOX-B7 is regulated by extracellular matrix-dependent signals in mammary epithelial cells. J Cell Biochem. 1998,71 ( 2 ), 310- 312.
  • 9Zerucha T, Ekker M. Distal-less-related homeobox genes of vertebrates: evolution, function, and regulation. Biochem Cell Biol,2000,78(5): 593-601.
  • 10Fu S, Stevenson H, Strovel JW, et al. Distinct functions of two isoforms of a homeobox gene, BP1 and DLX7, in the regulation of the beta-globin gene. Gene, 2001, 278:131-139.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部