摘要
目的 探讨经纤维支气管镜局部加全身静脉化疗治疗晚期非小细胞肺癌的疗效。 方法 42例经病理学或细胞学证实的晚期非小细胞肺癌患者,随机分为对照组和治疗组各21例。对照组采用NP方案(长春瑞宾加顺铂)化疗,治疗组在使用NP方案化疗的基础上,采用Olympus BF型纤维支气管镜及配套的NM-3K型注射针注入长春瑞宾10mg至瘤体中央及周围。 结果 对照组21例中,完全缓解3例(14.3％),部分缓解7例(33.3％),无变化11例(52.4％),有效率47.4％;治疗组21例中,完全缓解7例(33.3％),部分缓解10例(47.6％),无变化4例(19.1％),有效率80.9％,二组治疗有效率有显著性差异(P<0.05)。1年生存率治疗组为66.7％,对照组为31.3％,治疗组明显高于对照组(P<0.05)。 结论 经纤维支气管镜局部加全身静脉化疗治疗晚期非小细胞肺癌,能使瘤体缩小或消失,且能明显缓解患者临床症状,提高近期临床疗效及生存率,是一种有效的姑息治疗方法。
Objective To explore the effectiveness of treatment in advanced non - small cell lung carcinoma with trans - bronchoscopic chemotherapy, combined with systemic chemotherapy. Methods Forty - two patients with advanced non-small cell lung carcinoma confirmed by pathology or cytology were divided into treated group (n =21) and control group (n = 21) randomly, The control group were treated only by intravenous chemotherapy with the routine NP (navelbine and cisplatin) regimen, while the treated group received intravenous chemotherapy with the routine NP regimen and trans - bronchoscopic injection of navelbine 10mg into the centre of the tumor and the surroundings. Results In the control group (n - 21 ) , 3 patients (14.3% )were completely cured and 7(33.3% ) achieved partial recovery, while 11 patients had no change; the effective rate was 47. 4% . In the treated group, 7 patients (33. 3% ) were completely cured and 10 (47.6% )had partial recovery, and 4 no change, the effective rate was 80. 9% , efficacy of treated group was significantly higher than the control group (P <0.05). The survival rate of the treated group was 66. 7% , while the control group was 31.3% . The one year survival rate of the treated group was significantly higher than the control group (P <0.05) Conclusion Advanced non-small cell lung carcinoma treated by trans -bronchoscopic chemotherapy and intravenous chemotherapy with the routine regimen can remarkably reduce the size of tumor, relieve clinical symptoms and improve clinical effectiveness and increase the survival rate. This is considered to be an effective palliative treatment.
出处
《上海第二医科大学学报》
CSCD
2003年第3期245-247,共3页
Acta Universitatis Medicinalis Secondae Shanghai
