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Effect of decoy-oligodeoxynucleotides on expression of inflammation mediators in pMΦ cells from rats 被引量:3

Effect of decoy-oligodeoxynucleotides on expression of inflammation mediators in pMΦ cells from rats
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摘要 Objective: To study the effect of decoy-oligodeoxynucleotides (decoy-ODNs) in dumbbell shape with the oligodeoxynucleotide sequence similar to nuclear factor kappa B (NF-κB) cis-elements on expression of inflammation mediators in pMΦ cells from rats. Methods: With carriers of cationic liposomes, decoy-ODNs were transfected into pMΦ cells of rats. Then the inhibiting effects of the decoy-ODNs on tumor necrosis factor α (TNFα), interleukin-6 (IL-6) and IL-10 were analyzed. Results: Decoy-ODNs could decrease the expression of TNFα and IL-6 in dose-dependent fashion but had weaker inhibiting effect on IL-10. Conclusions: Decoy-ODNs targeting NF-κB can decrease the expression of inflammatory mediators in pMΦ cells from rats.
出处 《Chinese Journal of Traumatology》 CAS 2003年第6期363-369,共7页 中华创伤杂志(英文版)
基金 ThisstudywassupportedbytheNationalNaturalScienceFoundationofChina (No .30 170 36 7),theTenth FiveYearPlanofMilitaryCommand (No .0 1MB113)andMajorBasicResearchDevelopmentProgramofChina (No .G19990 5 4 2 0 3)
关键词 Tumor necrosis factor Inflammation mediators Nuclear factor kappa B Decoy-oligodeoxynucleotides 炎症 炎性介质 细胞因子 decoy-ODNs pMΦ细胞 白细胞介素
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