摘要
目的 :根据老年急性髓细胞白血病 (AML)的临床特点 ,评估常规剂量阿糖胞苷 (Ara C)作为诱导缓解治疗方案的疗效。方法 :对 2 5例老年AML患者以常规剂量Ara C(2 0 0mg m2 )静脉输注 ,1次 d ,连用 7天。获完全缓解后按原方案最多再进行 3个疗程的巩固 维持治疗。结果 :诱导化疗阶段完全缓解 12例 (4 8% ) ,早期死亡 2例 (8% ) ,化疗诱导期死亡 4例(16 % ) ,中位生存期 6 1个月 ,而不良反应以感染、出血为主。结论 :老年AML具有独特的生物学及临床特征 ,适于常规剂量Ara
Objective:To evaluate the curative effect of normal dosage Ara-C as induced remission program,accor-ding to the clinical characteristics in elderly patients with acute myeloid leukemia(AML).Methods:The normal dosage Ara-C(200 mg/m 2,iv.once a day,seven days successively)was used in 25 cases with AML. After completely remission, the same program was used to maintain treatment of three circulations at most.Results:In the inductive phase,the completely remission rate was 48%, the early mortality rate was 8%, the mortality rate of inductive phase was 16%, and the average survival period was 6.1 months.The adverse effects were infection and bleeding.Conclusion:AML in elderly patients has distinctive biology and clinical characteristics, and it is suitable to use normal dosage Ara-C to treat.
出处
《汕头大学医学院学报》
2004年第1期28-29,共2页
Journal of Shantou University Medical College
