摘要
目的 :探讨恶性心包积液经导管引流并腔内化疗的疗效及不良反应。方法 :2 8例恶性心包积液采用B超定位心包穿刺置管引流心包积液 ,连续 3d ,积液消失后第 1d以 0 .9%氯化钠溶液冲洗并腔内注射顺铂 (DDP) 6 0mg ,OK 4 32 10g、地塞米松 5mg心包腔内注射。 结果 :腔内化疗 1次积液消失者 3例 ,化疗 2次积液消失 12例 ,化疗 3次积液消失 6例 ,CR 75 %( 2 1/ 2 8) ,PR 14 .3% ( 4 / 2 8) ,RR 89.3% ( 2 5 / 2 8) ,NC 10 .7% ( 3/ 2 8)。结论 :导管置管治疗恶性心包积液 ,操作简单 ,疗效好 ,副作用少。
Objective: To evaluate the effect and side effect of cathetel drainage combined with catheter chemotherapy in cavity on malignant pericardial effusion.Methods: 28 patients with malignant pericardial effusion received the pericardiocentesis guided under B mode ultrasonography, the pericardial effusion was drawn with catheter for 3 days. followed by pericardial cavity washed with nornal saline and perfused with DDP 60 mg in first day after the effusion disappeared, and OK 432 10 g and dexamethasone 5 mg was injected into pericardial cavity in day 1 3. Methods: The effusion disappeared when chemotherapgy in cavity for one time in three cases, for two times in 12 cases, for three times in six cases. CR,PR, NC, and RR were 75%(21/28), 14.3% (4/28)10,7%(3/28), and 89.3% (25/28), respectively, when the chemotherapies were completed.Conclusion: This method of pericardiocentesis and chemotheraoy is safe and effective, the procedure is simple and less side effects.
出处
《中国药师》
CAS
2004年第5期386-387,共2页
China Pharmacist
关键词
心包积液
恶性
引流
化疗
Malignant pericardial effusion
Drainage
Chemotherapy
