摘要
目的观察585nm脉冲染料激光治疗皮肤血管异常性疾病的副作用及相关因素。方法回顾性分析500例患者经585nm脉冲染料激光治疗后的副作用及与疾病种类、治疗次数、治疗能量的关系。结果500例患者中术后>1个月发生副作用者66例(13.2%),其中色素沉着35例(7.0%),色素减退12例(2.4%),萎缩性瘢痕17例(3.4%),增生性瘢痕2例(0.4%)。术后>6个月仍有皮肤异常者24例(4.8%),其中色素沉着7例(1.4%),色素减退2例(0.4%),萎缩性瘢痕13例(2.6%),增生性瘢痕2例(0.4%)。色素沉着、色素减退、萎缩性瘢痕发生率在激光能量密度≥8.0J/cm2级高于其他能量级,差异有显著意义(P<0.05)。草莓状血管瘤组萎缩性瘢痕发生率高于其他病种组,差异有显著意义(P<0.05)。结论出现副作用与治疗次数无关,与激光能量密度、疾病种类有关。585nm脉冲染料激光治疗皮肤血管异常性疾病是安全的,无连续激光治疗后引起的增生性瘢痕、持续性色素沉着等副作用。
Objective To investigate the side effects and correlation factors of 585 nm pulsed dye laser in treatment of the skin vascular abnormalities. Methods To analyze the relationship between the side effects and the types of diseases,the session and the energy of treatment by reviewing 500 cases patients treated by 585 nm pulsed dye laser. Results There were 66 cases(13.2%) occurring side effects after one month of treating among 500 patients, in which temporary pigmentation was in 35 cases(7.0%), temporary pigment dropping in 12 cases(2.4%), spot atrophy of scar in 17 cases(3.4%),hyperplasia of scar in 2 cases(0.4%).Skin was still abnormal in 24 cases after six months of operation(4.8%),in which pigmentation in 7 cases(1.4%), pigment dropping in 2 cases(0.4%),atrophy of scar in 13 cases(2.6%),hyperplasia of scar in 2 cases(0.4%).The occurring rate of pigmentation,pigment dropping,atrophy of scar in level of energy≥8.0 J/cm2 were higher than other levels,P<0.05, the difference was significant.The occurring rate of atrophy of scar in group of strawberry hemangioma was higher than other groups,P<0.05, the difference was significant. Conclusions Occurred side effects have nothing to do with the frequency of treatment. It has something to do with the energy density of treatment and the types of diseases, The 585 nm pulsed dye laser hasn′t such the side effects as the hyperplasia of scar, continued pigmentation like the continuous lasers. It′s safe in treating the vascular abnormalities.
出处
《中国激光医学杂志》
CAS
CSCD
2004年第2期101-104,共4页
Chinese Journal of Laser Medicine & Surgery
