摘要
目的 探讨年轻妇女卵巢上皮细胞癌的临床特点、生存率和影响预后的因素。方法回顾分析 1985～ 1997年收治的 4 5 5例卵巢上皮细胞癌患者的临床资料。生存率采用Kaplan Meier方法计算 ,利用Cox风险比例回归模型分析比较影响患者预后的独立因素。结果 ≤ 4 0岁组92例 ,>4 0岁 36 3例。≤ 4 0岁组早期、高分化、黏液性癌所占比例明显高于 >4 0岁组 ,浆液性癌、腹水、肿瘤残存所占比例低于 >4 0岁患者 ,差异均有显著性 (P <0 .0 5 )。≤ 4 0岁组和 >4 0岁组的 5年生存率分别为 79.5 %和 2 8.2 % ,差异均有极显著性 (P <0 .0 0 1)。单因素分析两组间同一临床分期、组织类型、分级、肿瘤残存情况等显示 ,在相同情况下 ,≤ 4 0岁患者的生存率明显高于 >4 0岁者。多因素分析显示 ,临床分期、肿瘤残存情况和年龄为影响预后的独立因素。结论 ≤ 4 0岁的卵巢上皮细胞癌患者 ,其早期、Ⅰ级、黏液性囊腺癌所占比例高 ,肿瘤残存小 ,腹水少 ,总的 5年生存率高。临床分期、肿瘤残存情况、年龄是影响卵巢上皮细胞癌预后的独立因素。
Objective To evaluate the clinical characteristics, survival rate and prognosis of young patients with epithelial ovarian carcinoma. Methods The clinic data of 455 women with epithelial ovarian carcinoma were reviewed. Kaplan Meier method was used to calculate the survival rate. Cox proportional hazards regression model was used to determine the independent effect of each variable on survival. Results Of 445 patients with epithelial ovarian carcinoma, 92 were ≤40 years of age and 363 were older. Higher incidence of early stage, well differentiation and mucous cell type but lower incidence of serous cell type, ascites and residual tumors were found in the younger group. The overall 5 year survival rates were 79.55% in ≤40 years group and 28.2% in >40 years group ( P <0.001). Univariate analysis showed that the survival rate of patients≤40 years was significantly higher than that of >40 years. Only age, stage and residual disease were found to be the significant independent prognostic factors by the multivariate analysis. Conclusion Epithelial ovarian carcinoma in patients with age ≤40 has higher incidence of early stage, well defferetiation and mucous cystadenocarcinoma as well as a higher 5 year survival rate but lower possibility of residual tumor and ascites. Stage, residual tumor size and age are independent prognostic factors of epithelial ovarian carcinoma. [
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2003年第3期264-267,共4页
Chinese Journal of Oncology
