摘要
目的 :探讨芬妥拉明的镇痛作用。方法 :采用热板法测定慢性神经痛小鼠缩爪反应潜伏期(HWL)和正常小鼠扭体数作为痛阈指标 ,观察腹腔注射 (ip)芬妥拉明的镇痛作用。结果 :ip 4mg/Kg芬妥拉明 1～ 3d小鼠HWL明显增加和扭体数明显减少 (P <0 .0 0 1)。结论 :芬妥拉明对正常或神经病理性痛小鼠有镇痛作用。
Objective: To investigate the analgesic effects of phentolamine. Methods: The latency of hindpaw withdrawal (HWL) on the hot-plate in mononeuropathy mice and writhing in intact mice were used to measure the pain threshold. The analgesic effects of intra-peritoneal injection phentolamine on HWL and writhing were observed. Results: There were significant increases on HWL and decreases on writhing at 1～3d IP4mg/Kg phentolamine ( P <0.001). Conclusion: The results suggest that the phentolamine could enhance the analgesic effect in mononeuropathy or normal mice.
出处
《中国疼痛医学杂志》
CAS
CSCD
2004年第2期102-104,共3页
Chinese Journal of Pain Medicine
关键词
芬妥拉明
镇痛作用
实验
缩爪反应潜伏期
扭体
Phentolamine
Analgesic effect
Hindpaw withdrawal latency (HWL)
Writhing
