摘要
应用酶联雌二醇亲和组化法(F_2—HRP法)对57例胃癌切除的新鲜标本,进行雌激素受体(ER)检测,发现胃癌中的ER阳性率为28％,女性ER阳性率高于男性,尤以≥50岁组更为显著(P<0.05)。在胃癌的组织类型中,粘液腺癌和印戒细胞癌的ER阳性率显著高于其他无粘液分泌的癌(P<0.05)。呈弥漫性生长的胃癌ER阳性率高于非弥漫性生长的胃癌。胃癌的ER阳性率与肿瘤的淋巴结转移也有一定的关系。以抗雌二醇ABC免疫组化法(ABC法)和葡聚糖包裹活性炭生化法(DCC法)作为E_2-HRP法的对照。在57例胃癌中E_2-HRP法与ABC法的符合率达95％(P<0.001)。在15例胃癌中,DCC法与E_2-HRP法的符合率为67％。
Fresh resected specimens of gastric carcinoma in 57 patients were studied forestrogen receptor(ER)level by E_2 -HRP histochemical method. A total 28% of positiverate was found. Females showed a higher ER positive rate,especially in those≥50 yearsof age(P<0.05). The ER positive rate was significantly higher in the tumors withmucin secretion than those without it (P<0.05). ER positive tomors occurred morefrequently in group of diffusely infiltrative growth pattern than that of nondiffuselyinfiltrative. There was also correlation between ER positive rate and metastasis of thetumors. The method was compared with ABC method and dextran coated charcoal bio-chemical assay (DCC). The conformability between E_2-HRP and ABC was 95%and wasstatistically significant(P<0.001). The conformability between E_2-HRP and DCC was67%.
出处
《肿瘤》
CAS
CSCD
北大核心
1992年第1期10-12,共3页
Tumor
