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谷氨酸作用于腹侧苍白球引起大鼠血压改变

Changes of blood pressure after glutamate stimulation on ventral pallidum in rats
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摘要 目的 : 本研究通过谷氨酸溶液作用于腹侧苍白球观察血压的改变 ,从而探讨腹侧苍白球对血压的调节功能。 方法 :取SD雄性大鼠 1 0只 ,应用立体定向技术 ,将一定体积、一定浓度的谷氨酸溶液以一定的速度作用于单侧腹侧苍白球 ,通过颈总动脉置管观察血压的变化。 结果 :谷氨酸作用于腹侧苍白球引起大鼠血压升高 ;从(1 0 3.1± 2 .7)mmHg上升至 (1 1 3.5± 9.3)mmHg(P <0 .0 1 )。 结论 :腹侧苍白球具有交感神经性的正向调节血压的功能。 Objective: To investigate the Ventral Pallidrm′s function of cardiovascular adjustment by observing the changes of the rats′blood pressure. Methods:Ten SD rats′blood pressure were respectively observed through a catheter in one of the common carotid arteries after unilateral Ventral Pallidum stimulation by certain concertration,certain volume glutamate solution under stereotaxic guidance. Results:Glutamate stimulation on Ventral Pallidum caused elevation of the rats′blood pressure,thechanges were significant. Conclusion:Ventral Pallidum has a role in regulating blood pressure. It belongs to behavior related pattern and sympathetic regulated.
出处 《医学研究生学报》 CAS 2004年第5期401-403,共3页 Journal of Medical Postgraduates
基金 国家自然科学基金资助项目 (批准号 :3 0 0 70 82 3 )
关键词 谷氨酸 腹侧苍白球 血压 大鼠 Glutamate stimulation Ventral pallidum Blood pressure Rats
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