摘要
目的探讨问质性膀胱炎(Interstitial cystitis,IC)新的治疗方法。方法29例IC患者随机分为A、B两组,A组(治疗组)15例,B组(对照组)14例。A组2％利多卡因20ml膀胱灌注10min后,0.2％透明质酸钠100 ml+地塞米松10 mg膀胱灌注,每周1次,共6周。B组用1:5000呋喃西林溶液替代0.2％透明质酸钠溶液,方法类同A组,观察两组用药后临床症状评分及治疗前后尿动力学指标。结果两组用药后临床症状评分比较差异具有显著性意义(P<0.01)。A组治疗前后尿动力学指标比较差异有显著意义(P<0.01),13例患者临床症状消失,10例患者膀胱容量明显增加。B组用药前后尿动力学指标比较差异无显著意义(P>0.05),4例患者临床症状消失,膀胱容量无明显改善。结论透明质酸钠膀胱灌注治疗间质性膀胱炎是一种有效、简便、易行的新治疗途径。
Objective To develop a novel therapy of interstitial cystitis (IC) .Methods A total of 29 cases of IC were divided into test (A, 15 cases) and control (B, 14 cases) groups. The patients in group A were treated by intravesical instillation with 20 ml of 2% idocaine at first and with 100 ml of 0.2% sodium hyluronate containing 10 mg of dexamethasone 10 min later, once a week for 6 weeks. The patients in group B were treated by the same method, however, the furacilin solution at a dilution of 1:5000 was used instead of 0.2% sodium hyaluronate. Evaluate the clinical symptoms and urodynamics of the 2 groups before and after treatment. Results The scores for clinical symptoms after treatment were significantly different in the 2 groups (P<0.01). In group A, significant difference between the urodynamics before and after treatment was observed (P < 0.01) , the clinical symptoms of 13 patients disappeared, and the vesical volumes of 10 patients increased significantly. However, in group B, no significant difference between the urodynamics before and after treatment was observed (P > 0.05) , only the clinical symptoms of 4 patients disappeared, and vesical volume showed no significant difference. Conclusion Intravesical instillation with sodium hyaluronate is an effective , simple and feasible method for therapy of interstitial cystitis.
出处
《中国生物制品学杂志》
CAS
CSCD
2004年第3期185-186,共2页
Chinese Journal of Biologicals
基金
深圳市科技计划项目课题(200304102).
