期刊文献+

β-内酰胺类抗生素的药动学/药效学研究进展 被引量:19

Development in pharmacokinetics/pharmacodynamics research of beta-lactam antibiotics
下载PDF
导出
摘要 综述了β-内酰胺类抗生素的药动学/药效学(PK/PD)研究进展,主要阐述了PK/PD综合参数确立的实验证据,掌握PK/PD参数有助于抗菌药物的合理应用,提高疗效,减少不良反应。 In order to promote rational use of antibiotics in clinics,reduce bacterial resistance and decrease ADRs of beta-lactam antibiotics, the recent development in pharmacokinetics/pharmacodynamics research of beta-lactam antibiotics, mainly the experimental evidences, were reviewed in this paper.
作者 梁蓓蓓 王睿
出处 《中国新药杂志》 CAS CSCD 北大核心 2004年第4期310-313,共4页 Chinese Journal of New Drugs
关键词 Β-内酰胺类抗生素 药动学 药效学 beta-lactams antibiotics pharmacokinetics pharmacodynamics
  • 相关文献

参考文献15

  • 1Thoma GV. Beta-lactam antibiotics: is continuous infusion the preferred method of administration? [J]. Ann Pharmacother,1995,29(4) :415 - 423.
  • 2Zhao X, Drlica K. Restricting the selection of antibiotic-resistant mutants:a general strategy derived from fluoroquinolone studies [J]. Clin Infect Dis ,2001,33(Suppl 3) :S147 - S156.
  • 3Zhao X, Drlica J. Restricting the selection of antibiotic-resistant mutant bacteria:measurement and potential use of the mutant selection window[J]. J Infect Dis,2002,185 (4): 561 - 567.
  • 4Craig WA, Ebert SC. Killing and regrowth of bacteria in vitro [J]. ScandJ Infect Dis, 1991,74(Suppl) :S63 - S70.
  • 5Ursula F. Integration of pharmacokinetics and pharrmacodynamics of imipenem in a human adapted mouse model [J]. Antimicrob Agents Chemother, 1991,35(9): 1905 - 1910.
  • 6Craig WA. Interrelationship between pharmacokinetics and pharmacodynamics in determining dosage regimens for broad-spectrum cephalosporins [J]. Diagn Microbiol Infect Dis, 1995,22(1 -2):89-96.
  • 7Lutsar I, Ahmed A. Pharmacodynamics and bactericidal activity of ceftriaxone therapy in experimental cephalosporin-resistant pneumococcal meningits [J]. Antimicrob Agents Chemother,1997,41(11) :2414 - 2417.
  • 8Craig WA. Antimicrobial resistance issues of the future[J]. Diagn Microbiol Infect Dis, 1996,25(4):213- 218.
  • 9Craig WA. The future-can we learn from the past[J]. Diagn Microbiol Infect Dis, 1997,27(1- 2) :49 - 53.
  • 10Bodiy SJK, Rodriguez V. A rondomized study of carbenicillin plus cefamandole or tobramycin in the treatment of febrile episodes in cancer patients[J]. Am J Med, 1979,67 (5): 608 - 616.

同被引文献141

引证文献19

二级引证文献142

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部