摘要
目的 :研究HSP2 7和HSP70在膀胱癌中的表达和意义。方法 :应用免疫组化SP法 ,检测 73例膀胱癌组织中的HSP2 7和HSP70的表达。结果 :HSP2 7和HSP70在膀胱癌中的阳性表达率分别为 4 5 .2 1% (33/73)和 34.2 5 % (2 5 /73)。HSP2 7的表达随分级和分期呈降低趋势 ,但组间无明显性差异 (P >0 .0 5 ) ;HSP70的表达与膀胱癌的分级和分期呈正相关 (P <0 .0 5 )。结论 :HSP2 7和HSP70的表达可作为判断膀胱癌恶性程度的指标 ,并为肿瘤化学治疗提供依据。
Objective: to study the expression and significance of heat shock protein27 and 70 in bladder carcinoma . Methods:Immunohistochemical manner for HSP27 and HSP70 were performed on 73 cases of bladder carcinoma. Results:the total positive rates of HSP27 and HSP 70 were 45.21%(33/73) and 34.25%(25/73). the positive rate of HSP27 was increased with the cleuelopment of grade and clinical stage of bladder carcinoma,but there was no association among the groups; the expression of HSP70 was associated with grade and clinical stage of bladder carcinoma. Conlusion: the expression of HSP27 and HSP70 can be used asar important pathological index and may be helpful for the treatment of bladder carcinoma.
