摘要
目的:分析急性白血病(AL)免疫表型特点及其临床意义。方法:采用单克隆抗体直接免疫荧光标记法的流式细胞术,对71例AL进行免疫表型检测。结果:71例AL患者以系列专一型表达为主,同时亦存在抗原交叉表达、不表达特异性抗原及混合型等情况。AL患者CD34和HLA蛳DR表达分别占56.3 %和61.9 %,M3患者均不表达HLA蛳DR。My+ALL患者完全缓解(CR)率(60.0 %)低于My - ALL患者CR率(80.6 %),两组相比有显著性差异(P<0.05)。CD+34 ALL与CD蛳34 ALL患者缓解率基本相同;CD+34 AML患者CR率(58.3 %)明显低于CD蛳34 AML患者CR率(88.9 %),两组相比有显著性差异(P<0.05)。结论:白血病免疫表型检测结合FAB分型可以提高诊断的准确率,部分免疫表型特征对判断预后有一定的意义。
Objective: To investigate the immunophenotype of acute leukemia(AL) and its clinical significance. Methods: Immunophenotype were examined by flow cytometry in 71 cases of AL. Results: Most patients mainly expressed lineage antigen related to their origin, but some patients had bilineage antigen expression or no specific CD antigen expression or mixed lineage. Expression of CD34 and HLA- DR were in 56.3 % and 61.9 % of AL patients, respectively. There was no HLA- DA expression in M3 patients. Complete remission(CR) rate in myeloid antigen positive ALL(60.0 %) was slightly lower than those in myeloid antigen negative ALL(89.5 %),but there was no statistic significant(P>0.05). CR rate in CD+34 ALL was almost the same as that in CD 34 ALL. CR rate in CD+34 AML was significantly lower than those in CD- 34 AML(58.3 % vs 88.9 %,P<0.05). Conclusion: The immunophenotype analysis of AL combined with morphology may help in AL diagnosis and expression of some specific lineage antigen had prognostic value.
出处
《白血病．淋巴瘤》
CAS
2004年第2期79-81,共3页
Journal of Leukemia & Lymphoma
