期刊文献+

不同亚型精神分裂症患者的认知损害与精神症状及血清IL-2水平的关系 被引量:6

A comparative study of the correlation between cognitive impairment,psychotic symptom and plasma IL-2 level in defferent subtype schizophrenia
下载PDF
导出
摘要 目的 探讨不同亚型精神分裂症患者认知功能损害与精神症状及血清白介素 - 2 (IL - 2 )水平之间的关系。方法 对 94例精神分裂症患者进行测验 ,评定其认知功能 ,即采用PANSS量表评定阴、阳性症状及分型 ,以数字划销测验 (CT)、修订韦氏成人记忆量表 (WMS -RC)、威斯康星卡片分类测验 (WCST) ,并用酶联免疫吸附法 (ELISA)测定血清IL - 2水平 ,比较认知功能损害与精神症状和血清IL - 2水平之间的差异。结果 阴性亚型、混合型的认知损害程度较阳性亚型重 ;各亚型中认知损害主要与阴性症状相关 ,与阳性症状无关 ;各亚型间血清IL- 2水平差异不显著 ;血清IL - 2水平与认知损害有关 ,但各亚型不同。结论 认知损害与精神症状及血清IL - 2水平之间的关系各亚型间存在差异。 Objective To explore the relationship between plasma IL-2 level,cognitive impairment and psychotic symptoms in defferent subtype schizophrenia.Methods 94 cases of patients with schizophrenia were divided into postive subtype group,negative subtype group and mixed subtype group.They were tested with PANSS,cancellation test,Weschler memory scale and Wsconsin card sort test,and measured plasma IL-2 level with ELISA at the same times,and compared with each other in the three groups,respectively.Results There was no difference in plasma IL-2 level at different subtype schizophrenia.The cognitive impairment of negative subtype group and mixed subtype group were more serious than that of postive subtype group.There were a postive correlation between cognitive impairment and negative symptoms in every subtype groups.Conclusion The correlation between cognitive impairment,psychotic symptoms and plasma IL-2 level my be different in different subtype group of schizophrenia.
出处 《四川精神卫生》 2004年第1期7-10,共4页 Sichuan Mental Health
关键词 精神分裂症亚型 认知损害 精神症状 血清白介素-2 Schizophrenia Cognitive impairment Psychotic symptoms Plasma IL-2 level
  • 相关文献

参考文献10

  • 1宋建成,吉中孚.对精神分裂症症状认识的演变[J].国外医学(精神病学分册),2000,27(1):23-27. 被引量:26
  • 2司天梅,舒良,刘平,林凯.首发精神分裂症患者的细胞免疫改变[J].中国神经精神疾病杂志,1999,25(1):48-49. 被引量:16
  • 3朱海兵,广州市精神病医院,郭扬波,广州市精神病医院,马崔,广州市精神病医院.白细胞介素-2与精神分裂症研究进展[J].国外医学(精神病学分册),2000,27(3):189-192. 被引量:17
  • 4何燕玲 诸索宇 张明园译.阳性与阴性症状量表中文版[Z].西安扬森制药有限公司赞助印刷,.1~68.
  • 5Licinilo J, Seibyl JP, Alten M, et al.Elevated CSF levels of intefleukin -2 in neuroleptic - free schizophrenic patients.Am J Psychiatry,1993,150(11) :1408.
  • 6Mar,Leepw H.Cognitive deficit measures in schizophrenia:factor structure and clinical correlates.Am J Psychiatry, 1997,154 (1) :39.
  • 7Rothermundt M,Arolt V,Weitzsch C, et al.Immunological dysfunction in schizophrenia:a systematic approach.Neuropsychobiology, 1998,37(4) :186 - 193.
  • 8Harvey P,Optimising.Cognitive function in patients with schizophrenia.New York: Gardiner Caldwell Communication Ltd, 1997.15 - 26.
  • 9杨甫德,王向群.精神分裂症认知功能(上)[J].临床精神医学杂志,2001,11(2):112-113. 被引量:43
  • 10安宝富,王长虹,成俊祥.影响精神分裂症认知障碍的因素[J].国外医学(精神病学分册),2003,30(1):13-15. 被引量:12

二级参考文献31

共引文献107

同被引文献143

引证文献6

二级引证文献86

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部