摘要
在无水乙醇的存在下,乙酰乙酸乙酯和苯肼为原料合成标题化合物。采用单因素实验法,得到最佳配比为乙酰乙酸乙酯:苯肼=1.05(摩尔比),无水乙醇50ml,反应温度70℃,反应2小时,再回流7小时,收率90.9％,产品纯度99.0％以上。
l-Phenyl-3-methyl-5-pyrazoIone was synthesized by the reaction of ethyl acetoacetate and phenyl hydrazine in ethanol. The optimum conditions were obtained by single factor orthogonal design method, the molar ratio of ethyl acetoacetate and phenyl hydrazine was 1.05:1, 50ml ethanol(anhydrous), reaction temperature 70 ℃, reaction time 2 hours and then refluxing for 7 hours, the yield was 90.9%, the purity was > 99.0%.
出处
《染料与染色》
CAS
2004年第2期114-115,共2页
Dyestuffs and Coloration
