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两种常用数量性状连锁分析方法的原理和进展 被引量:1

Two Approaches of Quantitative-Trait Linkage Analysis
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摘要 在复杂性状疾病的家系连锁研究中,Haseman Elston回归分析和方差组成模型是常用的两种数量性状连锁分析方法。前者主要针对同胞对的性状值差或和的平方进行回归分析;后者引用方差组成模型,将数量性状分解为遗传方差和环境方差,可估计二者对表型的影响。两种方法可应用于同胞对、核心家系或扩展家系,定位数量性状基因座。此文对这两种模型的原理、算法及其进展进行了综述,并给出了常用的统计软件包。 In this article, we discussed two model-free methods for detecting genetic linkage for quantitative traits, Haseman-Elston regression approach and variance components approach. The former is a regression approach for detecting linkage based on the squared difference or squared sums in quantitative trait values of sib-pairs and their estimated marker IBD scores. The latter can jointly model covariate effects along with variance components, including genetic component and non-genetic sources of variability. We have outlined the model assumption, the algorithm and the extensions for the both methods.
出处 《遗传》 CAS CSCD 北大核心 2004年第2期253-256,共4页 Hereditas(Beijing)
关键词 数量性状 连锁分析方法 原理 复杂性状疾病 H-E模型 方差组成模型 complex trait disease nonparametric linkage analysis quantitative trait H-E approach variance components
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参考文献27

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