摘要
赛庚啶(Cypr)对离体豚鼠气管平滑肌的静息张力无明显影响,但对组胺(His)、5-羟色胺(5-HT),乙酰胆碱(ACh)、氯化钾(KCI)所致的气管收缩作用均有明显的对抗作用,IC50值分别为(9.1±7.6)×10^(-9),(3.3±1.9)×10^(-8)、(4.6±0.8)×10^(-7),(5.3±1.0)×10^(-7)mol/L,维拉帕米(Ver埘KCI的拮抗作用明显强于其抗ACh的气管收缩作用,而Cypr抗ACh和抗KCI作用强度相似,普萘洛尔(Pro)完全取消异丙肾上腺素(Iso)抗ACh所致气管收缩作用,而对Cypr的抗ACh气管收缩作用无明显影响。结果提示,Cypr对抗以上4种激动剂所致气管收缩作用可能是分别直接作用于气管平滑肌的M受体、5-HT_2受体、H_1受体和钙通道所致。
This study showed that cyproheptadine (Cypr) did not have ob- vious effect on resting tension of smooth muscle of isolated guinea pig trachea preparations. But it had obvious antagonistic effect on the contraction of the trachea induced by His, 5-HT,ACh and KCl.The IC50 value was(9.1 ±7.6)×10-9 (3.3±1.9)×10-8,(4.6±0.8)×10-7, and (5.3± 1.0)× 10-7 mol/L respectively. The antagonism of Ver on traeheal contraction induced by KC1 was significantly greater (P<0.001) than by ACh. The antagonistic potencies of Cypr on the contraction induced by KC1 and ACh were similar. In the presence of 1 μmpl/L propranolol (Pro), the anti-ACh traeheal contracted action of Iso was completely abolished. However this action of Cypr was not obviously affcctedby Pro. These results suggest that the antagonistic effects of Cypr on contraction induced by the above four agonists, are mainly related to the action of Cypr in blocking M receptor, 5-HT2 receptor, H1 receptor or calcium channel of traeheal smooth muscle.
出处
《同济医科大学学报》
CAS
CSCD
北大核心
1992年第5期320-322,共3页
Acta Universitatis Medicinae Tongji
关键词
赛庚啶
药理学
cyproheptadine
verapamil
isoprenaline
guinea pig tracheal strips
