期刊文献+

胸腺癌患者临床病理特点和预后 被引量:12

Clinicopathological features and prognosis of thymic carcinoma
原文传递
导出
摘要 目的 分析胸腺癌患者的临床病理特点 ,探讨影响预后的因素。方法 整理 5 4例胸腺癌患者的临床资料和生存资料 ,按Masaoka标准分期。其中根治切除 18例 (其中类癌 9例 ) ,姑息切除 17例 ,探查 10例。运用寿命表法计算累积生存率 ,采用Logrank检验和Cox多因素分析模型进行回顾性预后研究。结果 全组术后 5年生存率为 4 4 .4 %。肿瘤位于前纵隔和无钙化是其特点 ,在鉴别诊断中起重要作用。肿瘤大小、病理类型、手术方式、是否外侵和术后复发是影响预后的重要因素。类癌与其他胸腺癌相比 ,病变较早 ,切除率较高 ,预后较好。结论 肿瘤大小、病理类型、手术方式、是否外侵和术后复发是影响胸腺癌预后的主要因素 ,分期指标的选择应参照该结果。胸腺癌的治疗应首先考虑完整切除 ,并根据病理类型辅以放化疗。 Objective To investigate the clinicopathologic features of thymic carcinoma and assess its prognostic factors. Methods A retrospective analysis was performed in 54 patients with thymic carcinoma who underwent surgical resection. Eighteen patients were treated by total resection of the tumor,17 partial resection and 10 exploratory thoracotomy. The clinical stage was determined according to Masaoka′s classification. The survival time and prognostic factors were evaluated by the log-rank and Cox multivariate analysis model. Results The overall 5-year survival rate was 44.4%. Being located in anterior mediastinum and noncalcification in the tumor pathognomonically played an important role in the differential diagnosis. According to the multivariate analysis,tumor maximum diameter (OR=1.84),histological subtype (OR=1.70),completeness of resection (OR= 1.37 ),tumor invasion of peritumoral organs (OR=1.32) and postoperative recurrence (OR=1.26) were significant prognostic factors. Compared with other subtypes,carcinoid tumor had the characteristics of earlier lesion,better resection rate and better prognosis. Conclusion The most important prognostic variables for thymic carcinoma are tumor maximum diameter,histological subtype,completeness of resection,tumoral invasion and postoperative recurrence. Complete resection followed by chemoradiotherapy should be considered as favorable on the basis of a definitive pathologic diagnosis.
出处 《中华肿瘤杂志》 CAS CSCD 北大核心 2004年第4期223-225,共3页 Chinese Journal of Oncology
关键词 胸腺癌 临床表现 病理特点 预后 肿瘤转移 Thymic neoplasms/surgery Thymic neoplasms/pathology Prognosis
  • 相关文献

参考文献11

  • 1Masaoka A, Monden Y, Nakahara K, et al. Follow-up study of thymomas with special reference to their clinical stages.Cancer, 1981,48:2485-2492.
  • 2Ritter JH, Wick MR. Primary carcinomas of the thymus gland. Semin Diagn Pathol, 1999,16:18-31.
  • 3Suster S, Moran CA. Spindle cell thymic carcinoma: clinicopathologic and immunohistochemical study of a distinctive variant of primary thymic epithelial neoplasm. Am J Surg Pathol, 1999, 23:691-700.
  • 4Yoneda S, Marx A, Heimann S, et al. Low-grade metaplastic carcinoma of the thymus. Histopathology,1999,35:19-30.
  • 5Quagliano PV. Thymic carcinoma: case reports and review. J Thorac Imaging, 1996, 11:66-74.
  • 6Rosado de Christenson ML, Abbott GF, Kirejczyk WM, et al. Thoracic carcinoids: radiologic-pathologic correlation. Radiographics, 1999,19: 707-736.
  • 7Lin KL, Chen CY, Hsu HH, et al. Ectopic ACTH syndrome due to thymic carcinoid tumor in a girl. J Pediatr Endocrinol Metab,1999, 12:573-578.
  • 8Tanaka A, Yamauchi A, Ohsawa H, et al. Clinical study of six thymic carcinomas including long-term survivors. Kyobu Geka, 1999,52:347-354.
  • 9Nakanishi F, Sakamoto K, Shijubo N, et al. Thymic anaplastic carcinoma successfully controlled by combination chemotherapy. Nihon Kokyuki Gakkai Zasshi, 1998,36:613-617.
  • 10Iyoda A, Yusa T, Hiroshima K, et al. Surgical resection combined with intrathoracic hyperthermic perfusion for thymic carcinoma with an intrathoracic disseminated lesion: a case report. Anticancer Res, 1999,19:699-702.

二级参考文献4

  • 1汪楣,杨宗贻,苗延浚,殷蔚伯,谷铣之.胸腺瘤105例临床分析[J].中华放射肿瘤学杂志,1991,0(1):16-20. 被引量:12
  • 2张大为.原发纵隔肿瘤及囊肿327例的外科治疗[J].中华肿瘤杂志,1985,7:123-123.
  • 3汪楣,中国放射肿瘤学,1994年,5期,14页
  • 4张大为,中华肿瘤杂志,1985年,7卷,123页

共引文献19

同被引文献143

  • 1张正平,侯晓婧,王志涛,田兴仓,孟淑萍,王霈,牛建栋,朱力.胸腺上皮肿瘤MRI表现WHO组织病理分型相关性研究[J].临床放射学杂志,2021,40(3):457-460. 被引量:4
  • 2汪楣,杨宗贻,张志贤,殷蔚伯,谷铣之.胸腺癌30例临床分析[J].中华放射肿瘤学杂志,1991,0(2):27-30. 被引量:3
  • 3刘梅,宋欣,陈玲红,李冰.胸腺癌58例临床病理分析[J].诊断病理学杂志,2005,12(6):409-412. 被引量:11
  • 4吴开良,蒋国梁,茅静芳,傅小龙,钱浩.51例胸腺癌治疗结果及影响预后因素分析[J].中华放射肿瘤学杂志,2006,15(1):19-22. 被引量:10
  • 5张志庸,陈涛,崔玉尚,李单青,李力,徐晓辉,郭峰,李泽坚.胸腺癌的外科治疗与预后[J].中国胸心血管外科临床杂志,2005,12(6):377-380. 被引量:12
  • 6Loehrer PJ,Jiroutek M,Aisner S,et al.Combined etoposide,ifosfamide,and cisplatin in the treatment of patients with advanced thymoma and thymic carcinoma:an intergroup trial.Cancer,2001,91:2010-2015.
  • 7Lucchi M,Ambrogi MC,Duranti L,et al Advanced stage thymomas and thymic carcinomas:results of multimodality treatments.Ann Thorac Surg,2005,79:1840-1844.
  • 8Koizumi T,Takabayashi Y,Yamagishi S,et al.Chemotherapy for advanced thymic carcinoma:clinical response to cisplatin,doxorubicin,vincristine,and cyclophosphamide (ADOC chemotherapy).Am J Clin Oncol,2002,25:266-268.
  • 9Wick MR,Scheithauer BW,Weiland LH,et al.Primary thymic carcinoma.AmJ Pathol,1982,6:13-630.
  • 10Suster S,Rosai J.Thymic carcinoma:a clinicopathologic study of 60cases.Cancer,1991,67:1025-1032.

引证文献12

二级引证文献22

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部