摘要
目的 :探讨血管内皮生长因子 (VEGF)及其受体 (Flt ,Flk)在博莱霉素致大鼠肺纤维化肺组织中的表达及意义。方法 :采用免疫组化方法结合图像分析处理系统 ,研究VEGF及其受体在博莱霉素致肺纤维化大鼠肺组织中的免疫反应。结果 :VEGF在正常对照组大鼠肺组织中呈弱表达 ,在肺纤维化大鼠肺组织中呈高表达。Flt及Flk在正常对照组大鼠肺组织中呈弱表达 ,在肺纤维化大鼠肺组织中呈较高表达。结论
Objective:To study vascular endothelial growth factor (VEGF) and its receptors were expressed in lungs of rat with bleomycin-induced pulmonary fibrosis. Methods: We analysed the immunoreaction of VEGF in pulmonary tissues of bleomycin-induced pulmonary fibrosis rat with immunohitochemical techniques and image processing system. Results: The expression of VEGF and its receptors in pulmonary tissues of bleomycin-induced pulmonary fibrosis wore higher than those of normal pulmonary tissues of rats. Conclusion: The expression of VEGF and its receptors might be related with the pathogenesis and progress of pulmonary fibrosis.
出处
《青海医药杂志》
2004年第3期1-4,64,共5页
Qinghai Medical Journal
