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XRCC1基因多态与肿瘤遗传易感性研究进展 被引量:9

Research development of the gene XRCC1 dpolymorphisms and cancers susceptibility
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摘要 X射线交错互补修复基因 1 (XRCC1 )通过直接与聚合酶 β、DNA连接酶Ⅲ和多聚ADP核糖聚合酶形成复合物 ,共同参与因电离辐射和氧化损伤引起的碱基切除修复和单链断裂修复。XRCC1基因中存在 3个单核苷酸多态位点 ,各位点多态对各种肿瘤遗传易感性的影响不一。
出处 《国外医学(肿瘤学分册)》 2004年第5期323-326,共4页 Foreign Medical Sciences (Cancer Section)
基金 国家自然科学基金资助项目 ( 3 0 3 712 3 6)
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