1Fitch JC,Rollins S,Matis L,et al.Pharmacology and biological efficacy of a recombinant,humanized,single-chain antibody C5 complement inhibitor in patients undergoing coronary artery bypass graft surgery with cardiopulmonary bypass.Circulation,1999;100:249
2Riedemann NC,Guo RF,Ward PA.The enigma of sepsis.J Clin Invest,2003;112:460-467
3Czermak BJ,Sarma V,Pierson CL,et al.Protective effects of C5a blockade in sepsis.Nat Med,1999;5:788-792
4Coopersmith CM,Stromberg PE,Dunne WM,et al.Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis.JAMA,2002;287:1716-1721
5Rivers E,Nguyen B,Havstad S,et al.Early goal-directed therapy in the treatment of severe sepsis and septic shock.N Eng J Med,2001;345:1368-1377
6Van den Berghe G,Wouters P,Weekers F,et al.Intensive insulin therapy in the critically ill patients.N Eng J Med,2001;345:1359-1367
7Martin GS,Mannino DM,Eaton S,et al.The epidemiology of sepsis in the United States from 1979 through 2000.N Eng J Med,2003;348:1546-1554
8Riedemann NC,Guo RF,Ward PA.Novel strategies for the treatment of sepsis.Nat Med,2003;9:517-524
9Bone RC,Sprung CL,Sibbald WJ.Definitions for sepsis and organ failure.Crit Care Med,1992;20:724-726
10Levy MM,Fink MP,Marshall JC,et al.2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference.Crit Care Med,2003;31:1250-1256
3Andrews P, Azoulay E, Antonelli M, et al. Year in review in Intensive Care Medicine, 2006. II. hffections and sepsis, haemodynamics, elderly, invasive and noninvasive mechanical ventilation, weaning, ARDS. Intensive Care Med, 2007,33 : 214- 229.
4Shimizu J, Yamazaki S, Takahashi T, et al. Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self- tolerance. Nat Immuno1,2002,3 : 135-142.
5Levy MM, Fink MP, Marshall JC, et al. 2001 SCCM/ESICM/ACCP/ ATS/SIS international sepsis definitions conference. Crit Care Med, 2003,31 : 1250-1256.
6Sakaguchi S, Sakaguchi N, Asano M, et al. Immunologic selftolerance maintained by cell expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune disease. Immunol, 1995,155,1151-1164.
7Wisnoski N, Chung CS, Chen Y. The Contribution of CD4+ CD25 + T-Regulatory-Cells to immune suppression in sepsis. Shock, 2007, 27:251-257.
8Monneret G, Debard AL, Venet F,et al. Marked elevation of human circulating CD4+ CD25+ regulatory T cells in sepsis induced immunoparalysis. Crit Care Med ,2003,31:2068-2071.
9Von Boehmer H. Mechanisms of suppression by suppressor T cells. Nat hnmuno1,2005 ,6 :338-344.
10Venet F,Pachot A,Debard AL. Human CD4+ CD25 + Regulatory T lymphocytes inhibit lipopolysaccharide-induced monocyte survival through a Fas/Fas ligand-dependent mechanism. J Immunol,2006, 177:6540-6547.