摘要
目的 探讨SF在肝损伤时的变化并分析用于肝损伤评估的可能性。 方法 对 10 2例HB、86例HA、5例DIH患者用ELISA定量测定其SF ,用化学法测定ALT、TB。 结果 HA、HB及DIH的急性期SF和ALT均明显增高 (P<0 0 1)。HA恢复初期多数患者ALT恢复正常 ,SF虽然有下降但仍未正常 ,与对照组比较差异有显著性 (P <0 0 1)。ALT、TB正常的HB患者SF明显增高 (P <0 0 1) ,并与ALT和 /或TB呈正相关 ;DIH急性期SF极度增高。重症肝炎ALT下降时 ,有SF持续升高。 结论 血清铁蛋白检测是评价肝功能状态的实用指标 。
Objective To study concentration change in serum ferritin(SF) in hepatic injury,and the possibility of using SF index to evaluate hepatic injury. Methods The concentration of SF,and serum glutamic-pyruvic transaminase(ALT),total bilirubin (TB) in 102 viral hepatitis B(HB) cases,86 viral hepatitis A(HA) cases and 5 drug-inducedl hepatitis(DH) cases were detected by ELISA and chemistry measurement method. Results The levels of SF and ALT in HA,HB and DIH increased significantly compared with the control group (P<0.01).In the HA patients at early stage of recovery,ALT level decreased to normal,while SF level also decreased but not to normal,and there was still significant increase as compared with the control group (P<0.01).The SF concentration increased (P<0.05) in the HB patients with normal ALT and TB levels and it significantly increased (P<0.01) in those HB patients with abnormal ALT and TB levels,the change in SF concentration was positively correlated with ALT and/or TB,The SF concentration increased greatly in the DIH patients at acute stage,When ALT level decreased the SF concentration continued to rise in the hepatitis A or B gravis. Conclusion SF assay was a kind of new laboratory marker in liver function evaluation,and could better reflect the actual pathological changes than ALT.
出处
《中国热带医学》
CAS
2004年第3期336-338,共3页
China Tropical Medicine
