摘要
①目的 探讨早期诊断成人迟发型自身免疫性糖尿病 (LADA)的临床标准 ,及 1型糖尿病相关抗体与胰岛功能之间的关系。②方法 检测 10 6例初诊的 2型糖尿病病人的谷氨酸脱羧酶抗体 (GADA)和胰岛细胞抗体(ICA) ,比较发病年龄、体质量指数 (BMI)和典型症状与抗体阳性的关系 ,并进行为期 1.5年的随访 ,比较基础和随访结束时C 肽水平的变化。③结果 抗体阴性组 84例 (79.2 % ) ,抗体阳性组 2 2例 (2 0 .8% ) ,GADA+ 组 17例 (16 .0 % ) ,ICA+ 组 19例 (17.9% ) ,仅 1种抗体阳性组 15例 (14 .2 % ) ,双阳性组 7例 (6 .6 % )。抗体阳性组与抗体阴性组之间的C 肽水平无明显差异 ,在随访 1.5年后 ,抗体阳性组餐后 2hC 肽水平明显高于抗体阴性组 (t=9.84 1,P <0 .0 1)。④结论 发病年龄、BMI和多尿、多饮等症状并不能预测是否有抗体阳性 ,出现抗体阳性的
Objective To explore the diagnostic standards of latent autoimmune diabetes in adults(LADA), and the correlation between related antibodies and islet function in type 1 diabetes mellitus. Methods The glutamic acid decarboxylase antibody(GADA) and islet cell antibody(ICA) were measured in 106 patients with type 2 diabetes mellitus, and the correlations were compared between age, body mass index(BMI),symptom and antibody positivity. Results The results were: 84 cases in negative antibody group, 22 in positive antibody group, 17 in the GADA + group, and 19 in the ICA + group. 15 cases had only one positive antibody. The concentration of C-peptide in patients with positive antibodies did not differ significantly from those with negative antibodies(t=9.841,P<0.01). Conclusion The onset age, BMI and symptoms such as polyposia and polyuria could not predict the positive antibodies. The islet function decrease obviously in type 2 diabetes patients with positive antibodies.
出处
《齐鲁医学杂志》
2004年第2期137-138,140,共3页
Medical Journal of Qilu
